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Vol. 15, No. 20, pp. 2642-2647, October 15, 2001
1 Institute for Virus Research, Kyoto University, Kyoto
606-8507, Japan; 2 Department of Anatomy and Developmental
Biology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan
The basic helix-loop-helix (bHLH) gene Hes7, a putative
Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly
segmented and their anterior-posterior polarity is disrupted. As a
result, the somite derivatives such as vertebrae and ribs are severely disorganized. Although expression of Notch and its ligands is not
affected significantly, the oscillator and Notch modulator lunatic
fringe is expressed continuously throughout the mutant PSM. These
results indicate that Hes7 controls the cyclic expression of
lunatic fringe and is essential for coordinated somite segmentation.
[Key Words: bHLH; Hes7; lunatic fringe; Notch; somite segmentation; oscillation]
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