![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, No. 20, pp. 2702-2719, October 15, 2001
1 Laboratoire de développement et différenciation
cardiaques, Institut de recherches cliniques de Montréal (IRCM),
Montréal, Québec, Canada H2W 1R7; 2 Department of
Medicine, Division of Experimental Medicine, McGill University,
Montréal, Québec H3A 1A3, Canada; 3 Département de
pharmacologie, Université de Montréal, Montréal, Québec H3C
1AC, Canada; 4 Laboratoire de signalisation et
croissance cellulaire, IRCM, Montréal, Québec, Canada H2W 1R7;
5 Department of Pediatrics, Children's Hospital Medical
Center, Cincinnati, Ohio 45229, USA
Rho-like GTPases play a pivotal role in the orchestration of changes
in the actin cytoskeleton in response to receptor stimulation, and have
been implicated in transcriptional activation, cell growth regulation,
and oncogenic transformation. Recently, a role for RhoA in the
regulation of cardiac contractility and hypertrophic cardiomyocyte
growth has been suggested but the mechanisms underlying RhoA function
in the heart remain undefined. We now report that transcription factor
GATA-4, a key regulator of cardiac genes, is a nuclear mediator of RhoA
signaling and is involved in the control of sarcomere assembly in
cardiomyocytes. Both RhoA and GATA-4 are essential for sarcomeric
reorganization in response to hypertrophic growth stimuli and
overexpression of either protein is sufficient to induce sarcomeric
reorganization. Consistent with convergence of RhoA and GATA signaling,
RhoA potentiates the transcriptional activity of GATA-4 via a p38
MAPK-dependent pathway that phosphorylates GATA-4 activation domains
and GATA binding sites mediate RhoA activation of target cardiac
promoters. Moreover, a dominant-negative GATA-4 protein abolishes
RhoA-induced sarcomere reorganization. The identification of
transcription factor GATA-4 as a RhoA mediator in sarcomere
reorganization and cardiac gene regulation provides a link between RhoA
effects on transcription and cell remodeling.
[Key Words: RhoA; GATA-4; p38 MAPK; heart; cell signaling; transcription]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. S. Viger, S. M. Guittot, M. Anttonen, D. B. Wilson, and M. Heikinheimo Role of the GATA Family of Transcription Factors in Endocrine Development, Function, and Disease Mol. Endocrinol., April 1, 2008; 22(4): 781 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Appert-Collin, S. Cotecchia, M. Nenniger-Tosato, T. Pedrazzini, and D. Diviani The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates {alpha}1 adrenergic receptor-induced cardiomyocyte hypertrophy PNAS, June 12, 2007; 104(24): 10140 - 10145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Watanabe, M. Ma, K.-i. Hirabayashi, N. Gurusamy, P. T. Veeraveedu, P. Prakash, S. Zhang, A. J. Muslin, M. Kodama, and Y. Aizawa Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1269 - H1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Gardner, S. Chen, D. J. Glenn, and C. L. Grigsby Molecular Biology of the Natriuretic Peptide System: Implications for Physiology and Hypertension Hypertension, March 1, 2007; 49(3): 419 - 426. [Full Text] [PDF]
|
|
|
|
|
|
D. F. Chang, N. S. Belaguli, J. Chang, and R. J. Schwartz LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes PNAS, January 2, 2007; 104(1): 157 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Divine, L. J. Staloch, H. Haveri, C. W. Rowley, M. Heikinheimo, and T. C. Simon Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G297 - G306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tanaka, D. Nishimura, R.-C. Wu, M. Amano, T. Iso, L. Kedes, H. Nishida, K. Kaibuchi, and Y. Hamamori Nuclear Rho Kinase, ROCK2, Targets p300 Acetyltransferase J. Biol. Chem., June 2, 2006; 281(22): 15320 - 15329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Castellani, E. Salvati, S. Alema, and G. Falcone Fine Regulation of RhoA and Rock Is Required for Skeletal Muscle Differentiation J. Biol. Chem., June 2, 2006; 281(22): 15249 - 15257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Elliott, M. J. Solloway, N. Wise, C. Biben, M. W. Costa, M. B. Furtado, M. Lange, S. Dunwoodie, and R. P. Harvey A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery Development, April 1, 2006; 133(7): 1311 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Brown, D. P. Del Re, and M. A. Sussman The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits Circ. Res., March 31, 2006; 98(6): 730 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oka, M. Maillet, A. J. Watt, R. J. Schwartz, B. J. Aronow, S. A. Duncan, and J. D. Molkentin Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability Circ. Res., March 31, 2006; 98(6): 837 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, P. Paradis, A. Aries, H. Komati, C. Lefebvre, H. Wang, and M. Nemer Convergence of Protein Kinase C and JAK-STAT Signaling on Transcription Factor GATA-4 Mol. Cell. Biol., November 15, 2005; 25(22): 9829 - 9844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Bouchard, H. Taniguchi, and R. S. Viger Protein Kinase A-Dependent Synergism between GATA Factors and the Nuclear Receptor, Liver Receptor Homolog-1, Regulates Human Aromatase (CYP19) PII Promoter Activity in Breast Cancer Cells Endocrinology, November 1, 2005; 146(11): 4905 - 4916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Debrus, L. Rahbani, M. Marttila, B. Delorme, P. Paradis, and M. Nemer The Zinc Finger-Only Protein Zfp260 Is a Novel Cardiac Regulator and a Nuclear Effector of {alpha}1-Adrenergic Signaling Mol. Cell. Biol., October 1, 2005; 25(19): 8669 - 8682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Deaton, C. Su, T. G. Valencia, and S. R. Grant Transforming Growth Factor-{beta}1-induced Expression of Smooth Muscle Marker Genes Involves Activation of PKN and p38 MAPK J. Biol. Chem., September 2, 2005; 280(35): 31172 - 31181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oka, Y.-S. Dai, and J. D. Molkentin Regulation of Calcineurin through Transcriptional Induction of the calcineurin A{beta} Promoter In Vitro and In Vivo Mol. Cell. Biol., August 1, 2005; 25(15): 6649 - 6659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Munugalavadla, L. C. Dore, B. L. Tan, L. Hong, M. Vishnu, M. J. Weiss, and R. Kapur Repression of c-Kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation Mol. Cell. Biol., August 1, 2005; 25(15): 6747 - 6759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Zhou, D. J. Herrick, J. Rosenbloom, and B. Chaqour Cyr61 mediates the expression of VEGF, {alpha}v-integrin, and {alpha}-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells J Appl Physiol, June 1, 2005; 98(6): 2344 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Woods, G. Wang, and F. Beier RhoA/ROCK Signaling Regulates Sox9 Expression and Actin Organization during Chondrogenesis J. Biol. Chem., March 25, 2005; 280(12): 11626 - 11634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Afouda, A. Ciau-Uitz, and R. Patient GATA4, 5 and 6 mediate TGF{beta} maintenance of endodermal gene expression in Xenopus embryos Development, February 15, 2005; 132(4): 763 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Chandrasekar, S. Mummidi, W. C. Claycomb, R. Mestril, and M. Nemer Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-1-Akt-GATA4 Signaling Pathway in Cardiomyocytes J. Biol. Chem., February 11, 2005; 280(6): 4553 - 4567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, X.-h. Feng, and R. J. Schwartz SUMO-1 Modification Activated GATA4-dependent Cardiogenic Gene Activity J. Biol. Chem., November 19, 2004; 279(47): 49091 - 49098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Divine, L. J. Staloch, H. Haveri, C. M. Jacobsen, D. B. Wilson, M. Heikinheimo, and T. C. Simon GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1{alpha} Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G1086 - G1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho GATA transcription factors in the developing and adult heart Cardiovasc Res, August 1, 2004; 63(2): 196 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. LaVoie, D. Singh, and Y. Y. Hui Concerted Regulation of the Porcine Steroidogenic Acute Regulatory Protein Gene Promoter Activity by Follicle-Stimulating Hormone and Insulin-Like Growth Factor I in Granulosa Cells Involves GATA-4 and CCAAT/Enhancer Binding Protein {beta} Endocrinology, July 1, 2004; 145(7): 3122 - 3134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aries, P. Paradis, C. Lefebvre, R. J. Schwartz, and M. Nemer Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity PNAS, May 4, 2004; 101(18): 6975 - 6980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Frey, H. A. Katus, E. N. Olson, and J. A. Hill Hypertrophy of the Heart: A New Therapeutic Target? Circulation, April 6, 2004; 109(13): 1580 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Jaffe, P. Aspenstrom, and A. Hall Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways Mol. Cell. Biol., February 15, 2004; 24(4): 1736 - 1746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. LaVoie The Role of GATA in Mammalian Reproduction Experimental Biology and Medicine, December 1, 2003; 228(11): 1282 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Benchabane and J. L. Wrana GATA- and Smad1-Dependent Enhancers in the Smad7 Gene Differentially Interpret Bone Morphogenetic Protein Concentrations Mol. Cell. Biol., September 15, 2003; 23(18): 6646 - 6661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pikkarainen, H. Tokola, T. Majalahti-Palviainen, R. Kerkela, N. Hautala, S. S. Bhalla, F. Charron, M. Nemer, O. Vuolteenaho, and H. Ruskoaho GATA-4 Is a Nuclear Mediator of Mechanical Stretch-activated Hypertrophic Program J. Biol. Chem., June 20, 2003; 278(26): 23807 - 23816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Tremblay and R. S. Viger Transcription Factor GATA-4 Is Activated by Phosphorylation of Serine 261 via the cAMP/Protein Kinase A Signaling Pathway in Gonadal Cells J. Biol. Chem., June 6, 2003; 278(24): 22128 - 22135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Dusing, E. A. Florence, and D. A. Wiginton High-level activation by a duodenum-specific enhancer requires functional GATA binding sites Am J Physiol Gastrointest Liver Physiol, June 1, 2003; 284(6): G1053 - G1065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akazawa and I. Komuro Roles of Cardiac Transcription Factors in Cardiac Hypertrophy Circ. Res., May 30, 2003; 92(10): 1079 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Solloway and R. P. Harvey Molecular pathways in myocardial development: a stem cell perspective Cardiovasc Res, May 1, 2003; 58(2): 264 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gillio-Meina, Y. Y. Hui, and H. A. LaVoie GATA-4 and GATA-6 Transcription Factors: Expression, Immunohistochemical Localization, and Possible Function in the Porcine Ovary Biol Reprod, February 1, 2003; 68(2): 412 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pikkarainen, H. Tokola, R. Kerkela, T. Majalahti-Palviainen, O. Vuolteenaho, and H. Ruskoaho Endothelin-1-specific Activation of B-type Natriuretic Peptide Gene via p38 Mitogen-activated Protein Kinase and Nuclear ETS Factors J. Biol. Chem., January 31, 2003; 278(6): 3969 - 3975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Benitah, P. F. Valeron, H. Rui, and J. C. Lacal STAT5a Activation Mediates the Epithelial to Mesenchymal Transition Induced by Oncogenic RhoA. Mol. Biol. Cell, January 1, 2003; 14(1): 40 - 53. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Tremblay, F. Hamel, and R. S. Viger Protein Kinase A-Dependent Cooperation between GATA and CCAAT/Enhancer-Binding Protein Transcription Factors Regulates Steroidogenic Acute Regulatory Protein Promoter Activity Endocrinology, October 1, 2002; 143(10): 3935 - 3945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Boudreau, E. H. H. M. Rings, H. M. van Wering, R. K. Kim, G. P. Swain, S. D. Krasinski, J. Moffett, R. J. Grand, E. R. Suh, and P. G. Traber Hepatocyte Nuclear Factor-1alpha , GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription. IMPLICATION FOR THE DEVELOPMENTAL REGULATION OF THE SUCRASE-ISOMALTASE GENE J. Biol. Chem., August 23, 2002; 277(35): 31909 - 31917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Chockalingam, R. Cholera, S. A. Oak, Y. Zheng, H. W. Jarrett, and D. B. Thomason Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy Am J Physiol Cell Physiol, August 1, 2002; 283(2): C500 - C511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. He, M. Mendez, and M. C. LaPointe Regulation of the human brain natriuretic peptide gene by GATA-4 Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E50 - E57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Bruneau Transcriptional Regulation of Vertebrate Cardiac Morphogenesis Circ. Res., March 22, 2002; 90(5): 509 - 519. [Abstract] [Full Text] [PDF]
|
|
