![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, No. 22, pp. 2940-2944, November 15, 2001
Laboratory of Molecular Immunoregulation,
SAIC, National Cancer Institute at Frederick, Frederick,
Maryland 21702-1201, USA
Methylation patterns of the mammalian genome are thought to be
crucial for development. The precise mechanisms designating specific
genomic loci for methylation are not known. Targeted deletion of
Lsh results in perinatal lethality with a rather normal development. We report here, however, that Lsh
/
mice show substantial loss of methylation throughout the genome. The
hypomethylated loci comprise repetitive elements and single copy genes.
This suggests that global genomic methylation is not absolutely
required for normal embryogenesis. Based on the similarity of Lsh to
other SNF2 chromatin remodeling proteins, it suggests that alteration
of chromatin affects global methylation patterns in mice.
[Key Words: Lsh; methylation; SNF2; SWI/SNF complex; chromatin]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Gowher, H. Stuhlmann, and G. Felsenfeld Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b Genes & Dev., August 1, 2008; 22(15): 2075 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Aravin and D. Bourc'his Small RNA guides for de novo DNA methylation in mammalian germ cells Genes & Dev., April 15, 2008; 22(8): 970 - 975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Rauch, X. Zhong, X. Wu, M. Wang, K. H. Kernstine, Z. Wang, A. D. Riggs, and G. P. Pfeifer High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer PNAS, January 8, 2008; 105(1): 252 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Myant and I. Stancheva LSH Cooperates with DNA Methyltransferases To Repress Transcription Mol. Cell. Biol., January 1, 2008; 28(1): 215 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Takebayashi, T. Tamura, C. Matsuoka, and M. Okano Major and Essential Role for the DNA Methylation Mark in Mouse Embryogenesis and Stable Association of DNMT1 with Newly Replicated Regions Mol. Cell. Biol., December 1, 2007; 27(23): 8243 - 8258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Xi, H. Zhu, H. Xu, A. Schmidtmann, T. M. Geiman, and K. Muegge Lsh controls Hox gene silencing during development PNAS, September 4, 2007; 104(36): 14366 - 14371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Clark Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis Hum. Mol. Genet., April 15, 2007; 16(R1): R88 - R95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Nan, J. Hou, A. Maclean, J. Nasir, M. J. Lafuente, X. Shu, S. Kriaucionis, and A. Bird Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation PNAS, February 20, 2007; 104(8): 2709 - 2714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ikegami, M. Iwatani, M. Suzuki, M. Tachibana, Y. Shinkai, S. Tanaka, J. M. Greally, S. Yagi, N. Hattori, and K. Shiota Genome-wide and locus-specific DNA hypomethylation in G9a deficient mouse embryonic stem cells. Genes Cells, January 1, 2007; 12(1): 1 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Flaus, D. M. A. Martin, G. J. Barton, and T. Owen-Hughes Identification of multiple distinct Snf2 subfamilies with conserved structural motifs Nucleic Acids Res., May 31, 2006; 34(10): 2887 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ueda, M. Okano, C. Williams, T. Chen, K. Georgopoulos, and E. Li Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development, March 1, 2006; 133(6): 1183 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Takeshima, I. Suetake, H. Shimahara, K. Ura, S.-i. Tate, and S. Tajima Distinct DNA Methylation Activity of Dnmt3a and Dnmt3b towards Naked and Nucleosomal DNA. J. Biochem., March 1, 2006; 139(3): 503 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Lee and D. G. Skalnik CpG-binding Protein (CXXC Finger Protein 1) Is a Component of the Mammalian Set1 Histone H3-Lys4 Methyltransferase Complex, the Analogue of the Yeast Set1/COMPASS Complex J. Biol. Chem., December 16, 2005; 280(50): 41725 - 41731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Bultman, T. C. Gebuhr, and T. Magnuson A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in {beta}-globin expression and erythroid development Genes & Dev., December 1, 2005; 19(23): 2849 - 2861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Carlone, J.-H. Lee, S. R. L. Young, E. Dobrota, J. S. Butler, J. Ruiz, and D. G. Skalnik Reduced Genomic Cytosine Methylation and Defective Cellular Differentiation in Embryonic Stem Cells Lacking CpG Binding Protein Mol. Cell. Biol., June 15, 2005; 25(12): 4881 - 4891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Strunnikova, U. Schagdarsurengin, A. Kehlen, J. C. Garbe, M. R. Stampfer, and R. Dammann Chromatin Inactivation Precedes De Novo DNA Methylation during the Progressive Epigenetic Silencing of the RASSF1A Promoter Mol. Cell. Biol., May 15, 2005; 25(10): 3923 - 3933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Dodge, M. Okano, F. Dick, N. Tsujimoto, T. Chen, S. Wang, Y. Ueda, N. Dyson, and E. Li Inactivation of Dnmt3b in Mouse Embryonic Fibroblasts Results in DNA Hypomethylation, Chromosomal Instability, and Spontaneous Immortalization J. Biol. Chem., May 6, 2005; 280(18): 17986 - 17991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Banine, C. Bartlett, R. Gunawardena, C. Muchardt, M. Yaniv, E. S. Knudsen, B. E. Weissman, and L. S. Sherman SWI/SNF Chromatin-Remodeling Factors Induce Changes in DNA Methylation to Promote Transcriptional Activation Cancer Res., May 1, 2005; 65(9): 3542 - 3547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zemach, Y. Li, B. Wayburn, H. Ben-Meir, V. Kiss, Y. Avivi, V. Kalchenko, S. E. Jacobsen, and G. Grafi DDM1 Binds Arabidopsis Methyl-CpG Binding Domain Proteins and Affects Their Subnuclear Localization PLANT CELL, May 1, 2005; 17(5): 1549 - 1558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Gibbons Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes Hum. Mol. Genet., April 15, 2005; 14(suppl_1): R85 - R92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Santoro and I. Grummt Epigenetic Mechanism of rRNA Gene Silencing: Temporal Order of NoRC-Mediated Histone Modification, Chromatin Remodeling, and DNA Methylation Mol. Cell. Biol., April 1, 2005; 25(7): 2539 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fan, J. P. Hagan, S. V. Kozlov, C. L. Stewart, and K. Muegge Lsh controls silencing of the imprinted Cdkn1c gene Development, February 15, 2005; 132(4): 635 - 644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chen, N. Tsujimoto, and E. Li The PWWP Domain of Dnmt3a and Dnmt3b Is Required for Directing DNA Methylation to the Major Satellite Repeats at Pericentric Heterochromatin Mol. Cell. Biol., October 15, 2004; 24(20): 9048 - 9058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Lund and M. van Lohuizen Epigenetics and cancer Genes & Dev., October 1, 2004; 18(19): 2315 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Huang, T. Fan, Q. Yan, H. Zhu, S. Fox, H. J. Issaq, L. Best, L. Gangi, D. Munroe, and K. Muegge Lsh, an epigenetic guardian of repetitive elements Nucleic Acids Res., September 24, 2004; 32(17): 5019 - 5028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Santos and W. Dean Epigenetic reprogramming during early development in mammals Reproduction, June 1, 2004; 127(6): 643 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-Q. Sun, D. W. Lee, Q. Zhang, W. Xiao, E. H. Raabe, A. Meeker, D. Miao, D. L. Huso, and R. J. Arceci Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG Genes & Dev., May 1, 2004; 18(9): 1035 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Borkovich, L. A. Alex, O. Yarden, M. Freitag, G. E. Turner, N. D. Read, S. Seiler, D. Bell-Pedersen, J. Paietta, N. Plesofsky, et al. Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism Microbiol. Mol. Biol. Rev., March 1, 2004; 68(1): 1 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okuwaki and A. Verreault Maintenance DNA Methylation of Nucleosome Core Particles J. Biol. Chem., January 23, 2004; 279(4): 2904 - 2912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yan, E. Cho, S. Lockett, and K. Muegge Association of Lsh, a Regulator of DNA Methylation, with Pericentromeric Heterochromatin Is Dependent on Intact Heterochromatin Mol. Cell. Biol., December 1, 2003; 23(23): 8416 - 8428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chen, Y. Ueda, J. E. Dodge, Z. Wang, and E. Li Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b Mol. Cell. Biol., August 15, 2003; 23(16): 5594 - 5605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fan, Q. Yan, J. Huang, S. Austin, E. Cho, D. Ferris, and K. Muegge Lsh-deficient Murine Embryonal Fibroblasts Show Reduced Proliferation with Signs of Abnormal Mitosis Cancer Res., August 1, 2003; 63(15): 4677 - 4683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fujita, S. Watanabe, T. Ichimura, S. Tsuruzoe, Y. Shinkai, M. Tachibana, T. Chiba, and M. Nakao Methyl-CpG Binding Domain 1 (MBD1) Interacts with the Suv39h1-HP1 Heterochromatic Complex for DNA Methylation-based Transcriptional Repression J. Biol. Chem., June 20, 2003; 278(26): 24132 - 24138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Fuks, P. J. Hurd, R. Deplus, and T. Kouzarides The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase Nucleic Acids Res., May 1, 2003; 31(9): 2305 - 2312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. MUEGGE, H. YOUNG, F. RUSCETTI, and J. MIKOVITS Epigenetic Control during Lymphoid Development and Immune Responses: Aberrant Regulation, Viruses, and Cancer Ann. N.Y. Acad. Sci., March 1, 2003; 983(1): 55 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. G. Cezar, M. S. Bartolomei, E. J. Forsberg, N. L. First, M. D. Bishop, and K. J. Eilertsen Genome-Wide Epigenetic Alterations in Cloned Bovine Fetuses Biol Reprod, March 1, 2003; 68(3): 1009 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Brzeski and A. Jerzmanowski Deficient in DNA Methylation 1 (DDM1) Defines a Novel Family of Chromatin-remodeling Factors J. Biol. Chem., January 3, 2003; 278(2): 823 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Feinberg, M. Oshimura, and J. C. Barrett Epigenetic Mechanisms in Human Disease Cancer Res., November 15, 2002; 62(22): 6784 - 6787. [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Reyes, L. Hennig, and W. Gruissem Chromatin-Remodeling and Memory Factors. New Regulators of Plant Development Plant Physiology, November 1, 2002; 130(3): 1090 - 1101. [Full Text] [PDF]
|
|
|
|
|
|
C. Plass Cancer epigenomics Hum. Mol. Genet., October 1, 2002; 11(20): 2479 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-V. Gendrel, Z. Lippman, C. Yordan, V. Colot, and R. A. Martienssen Dependence of Heterochromatic Histone H3 Methylation Patterns on the Arabidopsis Gene DDM1 Science, September 13, 2002; 297(5588): 1871 - 1873. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Riddle and E. J. Richards The Control of Natural Variation in Cytosine Methylation in Arabidopsis Genetics, September 1, 2002; 162(1): 355 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ordway and T. Curran Methylation Matters: Modeling a Manageable Genome Cell Growth Differ., April 1, 2002; 13(4): 149 - 162. [Full Text] [PDF]
|
|
|
|
|
|
A. Bird DNA methylation patterns and epigenetic memory Genes & Dev., January 1, 2002; 16(1): 6 - 21. [Full Text] [PDF]
|
|
|
|
|
|
R. R. Meehan, S. Pennings, and I. Stancheva Lashings of DNA methylation, forkfuls of chromatin remodeling Genes & Dev., December 15, 2001; 15(24): 3231 - 3236. [Full Text] [PDF]
|
|
