.gif?ad=16839&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 15, No. 22, pp. 3039-3049, November 15, 2001
1 Department of Molecular Biology, 2 Department of
Molecular Genetics, 3 Department of Pathology, and
4 Howard Hughes Medical Institute, University of Texas
Southwestern Medical Center, Dallas, Texas 75239-9148, USA;
5 Laboratory of Molecular Morphogenesis, National Cancer
Institute-I.S.T., 16132 Genova, Italy; 6 Laboratoire de
Physiologie, Museum National d'Histoire Naturelle, UMR CNRS 8572, Paris, France
Neural crest cells play a key role in craniofacial development. The
endothelin family of secreted polypeptides regulates development of
several neural crest sublineages, including the branchial arch neural
crest. The basic helix-loop-helix transcription factor dHAND is also
required for craniofacial development, and in endothelin-1 (ET-1) mutant embryos, dHAND expression in the
branchial arches is down-regulated, implicating it as a transcriptional
effector of ET-1 action. To determine the mechanism that links ET-1
signaling to dHAND transcription, we analyzed the dHAND
gene for cis-regulatory elements that control transcription in
the branchial arches. We describe an evolutionarily conserved
dHAND enhancer that requires ET-1 signaling for activity. This
enhancer contains four homeodomain binding sites that are required for
branchial arch expression. By comparing protein binding to these sites
in branchial arch extracts from endothelin receptor A
(EdnrA) mutant and wild-type mouse embryos, we identified Dlx6,
a member of the Distal-less family of homeodomain proteins, as an
ET-1-dependent binding factor. Consistent with this conclusion,
Dlx6 was down-regulated in branchial arches from EdnrA
mutant mice. These results suggest that Dlx6 acts as an intermediary
between ET-1 signaling and dHAND transcription during
craniofacial morphogenesis.
[Key Words: dHAND/HAND2; neural crest; branchial arches; endothelin-1; endothelin receptor A; Dlx6]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Jeong, X. Li, R. J. McEvilly, M. G. Rosenfeld, T. Lufkin, and J. L. R. Rubenstein Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs Development, September 1, 2008; 135(17): 2905 - 2916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sato, Y. Kawamura, R. Asai, T. Amano, Y. Uchijima, D. A. Dettlaff-Swiercz, S. Offermanns, Y. Kurihara, and H. Kurihara Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development Development, February 15, 2008; 135(4): 755 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Voth, A. Oberthuer, T. Simon, Y. Kahlert, F. Berthold, and M. Fischer Identification of DEIN, a Novel Gene with High Expression Levels in Stage IVS Neuroblastoma Mol. Cancer Res., December 1, 2007; 5(12): 1276 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Potthoff and E. N. Olson MEF2: a central regulator of diverse developmental programs Development, December 1, 2007; 134(23): 4131 - 4140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nair, W. Li, R. Cornell, and T. F. Schilling Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish Development, January 15, 2007; 134(2): 335 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-B. Ruest, X. Xiang, K.-C. Lim, G. Levi, and D. E. Clouthier Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity Development, September 15, 2004; 131(18): 4413 - 4423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kaartinen, M. Dudas, A. Nagy, S. Sridurongrit, M. M. Lu, and J. A. Epstein Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells Development, July 15, 2004; 131(14): 3481 - 3490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Wieland, P Muschke, S Jakubiczka, M Volleth, B Freigang, and P F Wieacker Refinement of the deletion in 7q21.3 associated with split hand/foot malformation type 1 and Mondini dysplasia J. Med. Genet., May 1, 2004; 41(5): e54 - e54. [Full Text] [PDF]
|
|
|
|
|
|
T. Piotrowski, D.-g. Ahn, T. F. Schilling, S. Nair, I. Ruvinsky, R. Geisler, G.-J. Rauch, P. Haffter, L. I. Zon, Y. Zhou, et al. The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans Development, October 15, 2003; 130(20): 5043 - 5052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Kimmel, B. Ullmann, M. Walker, C. T. Miller, and J. G. Crump Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish Development, April 1, 2003; 130(7): 1339 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Miller, D. Yelon, D. Y. R. Stainier, and C. B. Kimmel Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint Development, April 1, 2003; 130(7): 1353 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yanagisawa, D. E. Clouthier, J. A. Richardson, J. Charite, and E. N. Olson Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development Development, March 15, 2003; 130(6): 1069 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Depew, T. Lufkin, and J. L. R. Rubenstein Specification of Jaw Subdivisions by Dlx Genes Science, October 11, 2002; 298(5592): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. F. Robledo, L. Rajan, X. Li, and T. Lufkin The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development Genes & Dev., May 1, 2002; 16(9): 1089 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abu-Issa, G. Smyth, I. Smoak, K.-i. Yamamura, and E. N. Meyers Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse Development, January 10, 2002; 129(19): 4613 - 4625. [Abstract] [Full Text] [PDF]
|
|
