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Vol. 16, No. 1, pp. 58-71, January 1, 2002
Department of Biochemistry and Biophysics, Program in Molecular
Biology and Biotechnology, University of North Carolina at Chapel Hill,
Chapel Hill, North Carolina 27599, USA
The stem-loop binding protein (SLBP) is the posttranscriptional
regulator of histone mRNA in metazoan cells. SLBP binds histone pre-mRNAs and facilitates 3'-end processing by promoting stable association of U7 snRNP with the pre-mRNA. To identify other factors involved in histone pre-mRNA processing, we used a modified yeast two-hybrid assay in which SLBP and its RNA target were coexpressed as
bait. A novel zinc finger protein, hZFP100, which interacts with the
SLBP/RNA complex but not with free SLBP, was cloned. The interaction
requires regions of SLBP that are important for histone pre-mRNA
processing. Antibodies to hZFP100 precipitate U7 snRNA, and expression
of hZFP100 in Xenopus oocytes stimulates processing of histone
pre-mRNA, showing that hZFP100 is a component of the processing machinery.
[Key Words: Histone mRNA; two-hybrid; U7 snRNP; zinc finger; RNA binding]
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