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Vol. 16, No. 10, pp. 1220-1233, May 15, 2002
1 The Dana-Farber Cancer Institute and
2 Department of Neurobiology, Harvard Medical School, Boston,
Massachusetts 02115, USA; 3 Department of Pathology,
International Medical Center of Japan, Tokyo 162-8655, Japan
Trigeminal nuclei and the dorsal spinal cord are first-order relay
stations for processing somatic sensory information such as touch,
pain, and temperature. The origins and development of these neurons are
poorly understood. Here we show that relay somatic sensory neurons and
D2/D4 dorsal interneurons likely derive from Mash1-positive
neural precursors, and depend on two related homeobox genes,
Rnx and Tlx-1, for proper formation. Rnx and Tlx-1
maintain expression of Drg11, a homeobox gene critical for the
development of pain circuitry, and are essential for the
ingrowth of trkA+ nociceptive/thermoceptive sensory afferents to their
central targets. We showed previously that Rnx is necessary for
proper formation of the nucleus of solitary tract, the target for
visceral sensory afferents. Together, our studies demonstrate a central
role for Rnx and Tlx-1 in the development of two major
classes of relay sensory neurons, somatic and visceral.
[Key Words: Rnx; Tlx-1; MASH1; DRG11; trkA; somatic sensory; D2; D4 interneurons]
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