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Vol. 16, No. 18, pp. 2339-2344, September 15, 2002
Department of Molecular and Cellular Biology, Harvard
University, The Biological Laboratories,
Cambridge, Massachusetts 02138, USA
Nodal is expressed at the lateral edges of the mouse node,
but its function in this "organizer" tissue remains unknown due to
the early lethality of Nodal mutant embryos. Here we used a genetic
strategy to selectively remove Nodal activity from the node. Embryos
lacking Nodal in the node fail to initiate molecular asymmetry in the
left lateral plate mesoderm and exhibit multiple left-right patterning
defects. Nodal may also act as a short-range signal to establish a
functional midline barrier. Our findings confirm that the mouse node is
instrumental in initiating left-right axis specification and identify
Nodal as the key morphogen regulating this process.
[Key Words: Nodal; node; left-right asymmetry; isomerism; lateral plate mesoderm; mouse]
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