![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 16, No. 19, pp. 2530-2543, October 1, 2002
1 Department of Biochemistry and 2 Howard Hughes
Medical Institute, St. Jude Children's Research Hospital, Memphis,
Tennessee 38105, USA; 3 Pharmaceutical Division, Bayer
Corporation, West Haven, Connecticut 06516, USA; 4 Department
of Molecular Sciences, University of Tennessee,
Memphis, Tennessee 38163, USA
c-Myc promotes cell growth and transformation by ill-defined
mechanisms. c-myc
/ mice die by embryonic day 10.5 (E10.5) with defects in growth and in cardiac and neural development.
Here we report that the lethality of c-myc/
embryos is also associated with profound defects in vasculogenesis and
primitive erythropoiesis. Furthermore, c-myc/
embryonic stem (ES) and yolk sac cells are compromised in their differentiative and growth potential. These defects are intrinsic to
c-Myc, and are in part associated with a requirement for c-Myc for the
expression of vascular endothelial growth factor (VEGF), as VEGF can
partially rescue these defects. However, c-Myc is also required for the
proper expression of other angiogenic factors in ES and yolk sac cells,
including angiopoietin-2, and the angiogenic inhibitors
thrombospondin-1 and angiopoietin-1. Finally,
c-myc/ ES cells are dramatically impaired in
their ability to form tumors in immune-compromised mice, and the small
tumors that sometimes develop are poorly vascularized. Therefore, c-Myc
function is also necessary for the angiogenic switch that is
indispensable for the progression and metastasis of tumors. These
findings support the model wherein c-Myc promotes cell growth and
transformation, as well as vascular and hematopoietic development, by
functioning as a master regulator of angiogenic factors.
[Key Words: c-Myc; VEGF; vasculogenesis; angiogenesis; tumorigenesis]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. He, H. Hu, R. Braren, S.-Y. Fong, A. Trumpp, T. R. Carlson, and R. A. Wang c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo Development, July 15, 2008; 135(14): 2467 - 2477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Dubois, C. Adolphe, A. Ehninger, R. A. Wang, E. J. Robertson, and A. Trumpp Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function Development, July 15, 2008; 135(14): 2455 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Rodrigues, S. T. Nerlick, E. L. White, J. L. Cleveland, and M. L. King A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular development Development, June 1, 2008; 135(11): 1903 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yekkala and T. A. Baudino Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc Expression Mol. Cancer Res., December 1, 2007; 5(12): 1296 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-w. Kim, P. Gao, Y.-C. Liu, G. L. Semenza, and C. V. Dang Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1 Mol. Cell. Biol., November 1, 2007; 27(21): 7381 - 7393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mizukami, Y. Kohgo, and D. C. Chung Hypoxia Inducible Factor-1 Independent Pathways in Tumor Angiogenesis Clin. Cancer Res., October 1, 2007; 13(19): 5670 - 5674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shchors and G. Evan Tumor Angiogenesis: Cause or Consequence of Cancer? Cancer Res., August 1, 2007; 67(15): 7059 - 7061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hou, C. Okamoto, K. Okada, N. Kawao, S. Kawata, S. Ueshima, and O. Matsuo c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells Cardiovasc Res, July 1, 2007; 75(1): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Harms and X. Chen Histone Deacetylase 2 Modulates p53 Transcriptional Activities through Regulation of p53-DNA Binding Activity Cancer Res., April 1, 2007; 67(7): 3145 - 3152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Patel and S. B. McMahon BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis J. Biol. Chem., January 5, 2007; 282(1): 5 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Podar, G. Tonon, M. Sattler, Y.-T. Tai, S. LeGouill, H. Yasui, K. Ishitsuka, S. Kumar, R. Kumar, L. N. Pandite, et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma PNAS, December 19, 2006; 103(51): 19478 - 19483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. N. Winteringham, R. Endersby, S. Kobelke, R. K. McCulloch, J. H. Williams, J. Stillitano, S. M. Cornwall, E. Ingley, and S. P. Klinken Myeloid Leukemia Factor 1 Associates with a Novel Heterogeneous Nuclear Ribonucleoprotein U-like Molecule J. Biol. Chem., December 15, 2006; 281(50): 38791 - 38800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Giuriato, S. Ryeom, A. C. Fan, P. Bachireddy, R. C. Lynch, M. J. Rioth, J. van Riggelen, A. M. Kopelman, E. Passegue, F. Tang, et al. Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch PNAS, October 31, 2006; 103(44): 16266 - 16271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shchors, E. Shchors, F. Rostker, E. R. Lawlor, L. Brown-Swigart, and G. I. Evan The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta Genes & Dev., September 15, 2006; 20(18): 2527 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mizukami, K. Fujiki, E.-M. Duerr, M. Gala, W.-S. Jo, X. Zhang, and D. C. Chung Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc J. Biol. Chem., May 19, 2006; 281(20): 13957 - 13963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bertl, H. Bartsch, and C. Gerhauser Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. Mol. Cancer Ther., March 1, 2006; 5(3): 575 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ryschich, P. Lizdenis, C. Ittrich, A. Benner, S. Stahl, A. Hamann, J. Schmidt, P. Knolle, B. Arnold, G. J. Hammerling, et al. Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma Cancer Res., January 1, 2006; 66(1): 198 - 211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Park, A. L. Shaffer, J. S. Kim, W. duBois, M. Potter, L. M. Staudt, and S. Janz Insertion of Myc into Igh Accelerates Peritoneal Plasmacytomas in Mice Cancer Res., September 1, 2005; 65(17): 7644 - 7652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. McLaughlin, M. R. Mazzoni, J. H. Cleator, L. Earls, A. L. Perdigoto, J. D. Brooks, J. A. S. Muldowney III, D. E. Vaughan, and H. E. Hamm Thrombin Modulates the Expression of a Set of Genes Including Thrombospondin-1 in Human Microvascular Endothelial Cells J. Biol. Chem., June 10, 2005; 280(23): 22172 - 22180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vidal, S. Zacharoulis, W. Guo, D. Shaffer, F. Giancotti, A. H. Bramley, C. de la Hoz, K. K. Jensen, D. Kato, D. D. MacDonald, et al. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow PNAS, May 10, 2005; 102(19): 6890 - 6895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lasorella, G. Rothschild, Y. Yokota, R. G. Russell, and A. Iavarone Id2 Mediates Tumor Initiation, Proliferation, and Angiogenesis in Rb Mutant Mice Mol. Cell. Biol., May 1, 2005; 25(9): 3563 - 3574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wilson, M. J. Murphy, T. Oskarsson, K. Kaloulis, M. D. Bettess, G. M. Oser, A.-C. Pasche, C. Knabenhans, H. R. MacDonald, and A. Trumpp c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation Genes & Dev., November 15, 2004; 18(22): 2747 - 2763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Nilsson, L. M. Nilsson, U. Keller, Y. Yokota, K. Boyd, and J. L. Cleveland Id2 Is Dispensable for Myc-Induced Lymphomagenesis Cancer Res., October 15, 2004; 64(20): 7296 - 7301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Elkon, K. I. Zeller, C. Linhart, C. V. Dang, R. Shamir, and Y. Shiloh In silico identification of transcriptional regulators associated with c-Myc Nucleic Acids Res., September 23, 2004; 32(17): 4955 - 4961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. E. Knies-Bamforth, S. B. Fox, R. Poulsom, G. I. Evan, and A. L. Harris c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism Cancer Res., September 15, 2004; 64(18): 6563 - 6570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rossiter, C. Barresi, J. Pammer, M. Rendl, J. Haigh, E. F. Wagner, and E. Tschachler Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation Cancer Res., May 15, 2004; 64(10): 3508 - 3516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Nilsson, K. H. Maclean, U. B. Keller, H. Pendeville, T. A. Baudino, and J. L. Cleveland Mnt Loss Triggers Myc Transcription Targets, Proliferation, Apoptosis, and Transformation Mol. Cell. Biol., February 15, 2004; 24(4): 1560 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ruddell, P. Mezquita, K. A. Brandvold, A. Farr, and B. M. Iritani B Lymphocyte-Specific c-Myc Expression Stimulates Early and Functional Expansion of the Vasculature and Lymphatics during Lymphomagenesis Am. J. Pathol., December 1, 2003; 163(6): 2233 - 2245. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-W. Zhang, Y. Su, O. V. Volpert, and G. F. V. Woude Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation PNAS, October 28, 2003; 100(22): 12718 - 12723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Maclean, U. B. Keller, C. Rodriguez-Galindo, J. A. Nilsson, and J. L. Cleveland c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL Mol. Cell. Biol., October 15, 2003; 23(20): 7256 - 7270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, N. Yang, D. Katsaros, W. Huang, J.-W. Park, S. Fracchioli, C. Vezzani, I. A. Rigault de la Longrais, W. Yao, S. C. Rubin, et al. The Oncogene Phosphatidylinositol 3'-Kinase Catalytic Subunit {alpha} Promotes Angiogenesis via Vascular Endothelial Growth Factor in Ovarian Carcinoma Cancer Res., July 15, 2003; 63(14): 4225 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ciarapica, J. Rosati, G. Cesareni, and S. Nasi Molecular Recognition in Helix-Loop-Helix and Helix-Loop-Helix-Leucine Zipper Domains. DESIGN OF REPERTOIRES AND SELECTION OF HIGH AFFINITY LIGANDS FOR NATURAL PROTEINS J. Biol. Chem., March 28, 2003; 278(14): 12182 - 12190. [Abstract] [Full Text] [PDF]
|
|
