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Vol. 16, No. 19, pp. 2566-2575, October 1, 2002
1 Department of Molecular Cell Biology, Utrecht University,
3584 CH Utrecht, The Netherlands; 2 Departmento de
Bioquímica Médica, Universidade Federal do Rio de Janeiro,
Rio de Janeiro, RJ 21941-590 Brasil
In plant meristems, dividing cells interpret positional information
and translate it into patterned cell differentiation. Here we report
the molecular identification of the Arabidopsis HOBBIT gene
that is required for cell division and cell differentiation in
meristems. We show that it encodes a homolog of the CDC27 subunit of
the anaphase-promoting complex (APC). HOBBIT partially complements a
yeast nuc2/cdc27 mutant. Unlike other CDC27 homologs in
Arabidopsis, its transcription is cell cycle regulated.
Furthermore, hobbit mutants show a reduction in
DR5 :: GUS auxin reporter gene expression and accumulate the AXR3/IAA17 repressor of auxin responses. HOBBIT activity may thus couple cell division to cell differentiation by
regulating cell cycle progression in the meristem or by restricting the
response to differentiation cues, such as auxin, to dividing cells.
[Key Words: APC3; auxin; BimA; meristem; Nuc2; pattern formation]
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