Genes and Development

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kostas, S. A.
Right arrow Articles by Fire, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kostas, S. A.
Right arrow Articles by Fire, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Vol. 16, No. 2, pp. 257-269, January 15, 2002

RESEARCH PAPER
The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans

Stephen A. Kostas,1,2 and Andrew Fire1,3

1 Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA; 2 Graduate Program in Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA

We have isolated mutations in a gene mls-1 that is required for proper specification of nonstriated muscle fates in Caenorhabditis elegans. Loss of MLS-1 activity causes uterine muscle precursors to forego their normal fates, instead differentiating as vulval muscles. We have cloned mls-1 and shown that the product is a member of the T-box family of transcriptional regulators. MLS-1 acts as a cell fate determinant in that ectopic expression can transform other cell types to uterine muscle precursors. Uterine muscle patterning is executed by regulation of MLS-1 at several different levels. The mls-1 promoter is activated by the C. elegans orthologs of Twist and Daughterless, but is only active in a subset of the lineage where these two transcription factors are present. mls-1 activity also appears to be regulated by posttranscriptional processes, as expression occurs in both uterine and vulval muscle precursors.

[Key Words: Muscle; myogenesis; T-box; asymmetric cell division; Twist; C. elegans]

3 Corresponding author.

GENES & DEVELOPMENT 16:257-269 © 2002 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/02 $5.00
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Genome Res.Home page
G. Zhao, L. A. Schriefer, and G. D. Stormo
Identification of muscle-specific regulatory modules in Caenorhabditis elegans
Genome Res., March 1, 2007; 17(3): 348 - 357.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. M. Amin, K. Hu, D. Pruyne, D. Terzic, A. Bretscher, and J. Liu
A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm
Development, January 1, 2007; 134(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
Y. Jiang, V. Horner, and J. Liu
The HMX homeodomain protein MLS-2 regulates cleavage orientation, cell proliferation and cell fate specification in the C. elegans postembryonic mesoderm
Development, September 15, 2005; 132(18): 4119 - 4130.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
R. Pocock, J. Ahringer, M. Mitsch, S. Maxwell, and A. Woollard
A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans
Development, May 15, 2004; 131(10): 2373 - 2385.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
K. Good, R. Ciosk, J. Nance, A. Neves, R. J. Hill, and J. R. Priess
The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos
Development, May 1, 2004; 131(9): 1967 - 1978.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
Y. Andachi
Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis
Genes Cells, April 1, 2004; 9(4): 331 - 344.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genome Res. Learn. Mem.
Protein Science RNA Genes Dev.