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Vol. 16, No. 23, pp. 3034-3045, December 1, 2002
1 Fred Hutchinson Cancer Research Center, Basic Sciences
Division, Seattle, Washington 98109-1024, USA; 2 Washington
University School of Medicine, Department of Genetics, St. Louis,
Missouri 63110, USA; 3 Vassar College, Department of
Biology, Poughkeepsie, New York 12604, USA
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early
cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of
the cell cycle in budding yeast. These proteins bind to Mcm1 and to a
typical homeodomain binding site. The expression of Yox1 is periodic
and directly correlated with its binding to, and repression of, ECB
activity. The absence of Yox1 and Yhp1 or the constitutive expression
of Yox1 leads to the loss of cell-cycle regulation of ECB activity.
Therefore, the cell-cycle-regulated expression of these repressors
defines the interval of ECB-dependent transcription. Twenty-eight
genes, including MCM2-7, CDC6, SWI4, CLN3, and a number of genes required during late M phase have been identified that are coordinately regulated by this pathway.
[Key Words: ECB; cell cycle; SWI4; CLN3; MCM2-7; transcription]
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