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Vol. 16, No. 3, pp. 295-300, February 1, 2002
Department of Genetics and Howard Hughes Medical Institute,
Harvard Medical School, Boston, Massachusetts 02115, USA
The Notch signaling pathway regulates the commitment and early
development of T lymphocytes. We studied Notch-mediated induction of
the pre-T cell receptor 
(pTa) gene, a
T-cell-specific transcriptional target of Notch. The pTa
enhancer was activated by Notch signaling and contained binding sites
for its nuclear effector, CSL. Mutation of the CSL-binding sites
abolished enhancer induction by Notch and delayed the up-regulation of
pTa transgene expression during T cell lineage commitment.
These results show a direct mechanism of stage- and tissue-specific
gene induction by the mammalian Notch/CSL signaling pathway.
[Key Words:
Notch; CSL; pre-TCR; enhancer; T lymphocytes]
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