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Vol. 16, No. 3, pp. 388-398, February 1, 2002
1 The Laboratory of Immunobiology, National Institutes of
Health, National Cancer Institute at Frederick, Frederick, Maryland
21702, USA; 2 Oral and Pharyngeal Cancer Branch, National
Institute of Dental and Craniofacial Research, National Institutes of
Health, Bethesda, Maryland 20892, USA
The JAK/STAT signal transduction pathway controls numerous events in
Drosophila melanogaster development. Receptors for the pathway
have yet to be identified. Here we have identified a Drosophila gene that shows embryonic mutant phenotypes identical to those in
the hopscotch (hop)/JAK kinase and marelle
(mrl)/Stat92e mutations. We named this gene
master of marelle (mom). Genetic analyses place mom's function between upd (the ligand) and
hop. We further show that cultured cells transfected with the
mom gene bind UPD and activate the HOP/STAT92E signal
transduction pathway. mom encodes a protein distantly related
to the mammalian cytokine receptor family. These data show that
mom functions as a receptor of the Drosophila JAK/STAT
signal transduction pathway.
[Key Words: Drosophila; JAK/STAT; signal transduction; cytokine receptor]
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