.GIF?ad=16177&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 16, No. 5, pp. 548-553, March 1, 2002
1 Kondoh Differentiation Signaling Project, Exploratory
Research for Advanced Technology (ERATO), Japan Science and Technology
Corporation (JST), Kinki Invention Center, Sakyo-ku, Kyoto 606-8305, Japan; 2 Institute for Molecular and Cellular Biology,
Osaka University, Suita, Osaka 565-0871, Japan; 3 Center for
Molecular and Developmental Biology, Graduate School of Science, Kyoto
University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan; 4
Center for Integrative Bioscience, Okazaki National Research
Institutes, Okazaki, Aichi 444-8585, Japan
In the developing spinal cord, signals from the roof plate are
required for the development of three classes of dorsal interneuron: D1, D2, and D3, listed from dorsal to ventral. Here, we demonstrate that absence of Wnt1 and Wnt3a, normally expressed in the roof plate,
leads to diminished development of D1 and D2 neurons and a compensatory
increase in D3 neuron populations. This occurs without significantly
altered expression of BMP and related genes in the roof plate.
Moreover, Wnt3a protein induces expression of D1 and D2 markers in the
isolated medial region of the chick neural plate, and Noggin does not
interfere with this induction. Thus, Wnt signaling plays a critical
role in the specification of cell types for dorsal interneurons.
[Key Words: Wnt signaling; neuronal specification; interneuron; spinal cord]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Liu, Y. Wang, P. M. Smallwood, and J. Nathans An Essential Role for Frizzled5 in Neuronal Survival in the Parafascicular Nucleus of the Thalamus J. Neurosci., May 28, 2008; 28(22): 5641 - 5653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Alvarez-Medina, J. Cayuso, T. Okubo, S. Takada, and E. Marti Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression Development, January 15, 2008; 135(2): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yoshida, T. Shimomura, T. Sakabe, K. Ishii, K. Gonda, S. Matsuoka, Y. Watanabe, K. Takubo, H. Tsuchiya, Y. Hoshikawa, et al. A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G1089 - G1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Nyholm, S.-F. Wu, R. I. Dorsky, and Y. Grinblat The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum Development, February 15, 2007; 134(4): 735 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamaguchi, S. Yonemura, and S. Takada Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse Development, December 1, 2006; 133(23): 4737 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Borello, B. Berarducci, P. Murphy, L. Bajard, V. Buffa, S. Piccolo, M. Buckingham, and G. Cossu The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis Development, September 15, 2006; 133(18): 3723 - 3732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Taneyhill and M. Bronner-Fraser Dynamic Alterations in Gene Expression after Wnt-mediated Induction of Avian Neural Crest Mol. Biol. Cell, November 1, 2005; 16(11): 5283 - 5293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Li, K. Misra, M. P. Matise, and M. Xiang Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord PNAS, July 26, 2005; 102(30): 10688 - 10693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kriks, G. M. Lanuza, R. Mizuguchi, M. Nakafuku, and M. Goulding Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord Development, July 1, 2005; 132(13): 2991 - 3002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Riccomagno, S. Takada, and D. J. Epstein Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh Genes & Dev., July 1, 2005; 19(13): 1612 - 1623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhao, C. Aviles, R. A. Abel, C. R. Almli, P. McQuillen, and S. J. Pleasure Hippocampal and visuospatial learning defects in mice with a deletion of frizzled 9, a gene in the Williams syndrome deletion interval Development, June 15, 2005; 132(12): 2917 - 2927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Charron and M. Tessier-Lavigne Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance Development, May 15, 2005; 132(10): 2251 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. ARENAS Engineering a Dopaminergic Phenotype in Stem/Precursor Cells: Role of Nurr1, Glia-Derived Signals, and Wnts Ann. N.Y. Acad. Sci., May 1, 2005; 1049(1): 51 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bok, M. Bronner-Fraser, and D. K. Wu Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear Development, May 1, 2005; 132(9): 2115 - 2124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Filippi, N. Tiso, G. Deflorian, E. Zecchin, M. Bortolussi, and F. Argenton The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord PNAS, March 22, 2005; 102(12): 4377 - 4382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Muller, K. Anlag, H. Wildner, S. Britsch, M. Treier, and C. Birchmeier The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord Genes & Dev., March 15, 2005; 19(6): 733 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Burstyn-Cohen, J. Stanleigh, D. Sela-Donenfeld, and C. Kalcheim Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition Development, November 1, 2004; 131(21): 5327 - 5339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord Development, November 1, 2004; 131(21): 5393 - 5403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Zhou, K. I. Pinson, and S. J. Pleasure Severe Defects in Dorsal Thalamic Development in Low-Density Lipoprotein Receptor-Related Protein-6 Mutants J. Neurosci., September 1, 2004; 24(35): 7632 - 7639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Marklund, M. Sjodal, B. C. Beehler, T. M. Jessell, T. Edlund, and L. Gunhaga Retinoic acid signalling specifies intermediate character in the developing telencephalon Development, September 1, 2004; 131(17): 4323 - 4332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov and K. J. Millen Control of Roof Plate Development and Signaling by Lmx1b in the Caudal Vertebrate CNS J. Neurosci., June 23, 2004; 24(25): 5694 - 5703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. V. Chizhikov and K. J. Millen Control of roof plate formation by Lmx1a in the developing spinal cord Development, June 1, 2004; 131(11): 2693 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Bulgakov, J. T. Eggenschwiler, D.-H. Hong, K. V. Anderson, and T. Li FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues Development, May 1, 2004; 131(9): 2149 - 2159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Zhou, C. Zhao, and S. J. Pleasure Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production and Radial Glial Scaffolding Abnormalities J. Neurosci., January 7, 2004; 24(1): 121 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes Development, December 1, 2003; 130(23): 5663 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Castelo-Branco, J. Wagner, F. J. Rodriguez, J. Kele, K. Sousa, N. Rawal, H. A. Pasolli, E. Fuchs, J. Kitajewski, and E. Arenas Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a PNAS, October 28, 2003; 100(22): 12747 - 12752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bach, Y. Lallemand, M.-A. Nicola, C. Ramos, L. Mathis, M. Maufras, and B. Robert Msx1 is required for dorsal diencephalon patterning Development, September 1, 2003; 130(17): 4025 - 4036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Alonso and E. Fuchs Stem cells in the skin: waste not, Wnt not Genes & Dev., May 15, 2003; 17(10): 1189 - 1200. [Full Text] [PDF]
|
|
|
|
|
|
T. Nakamura, M. Sano, Z. Songyang, and M. D. Schneider A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis PNAS, May 13, 2003; 100(10): 5834 - 5839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lyu, F. Costantini, E.-h. Jho, and C.-k. Joo Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells J. Biol. Chem., April 4, 2003; 278(15): 13487 - 13495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Persson, D. Stamataki, P. te Welscher, E. Andersson, J. Bose, U. Ruther, J. Ericson, and J. Briscoe Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity Genes & Dev., November 15, 2002; 16(22): 2865 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, N. Thekdi, P. M. Smallwood, J. P. Macke, and J. Nathans Frizzled-3 Is Required for the Development of Major Fiber Tracts in the Rostral CNS J. Neurosci., October 1, 2002; 22(19): 8563 - 8573. [Abstract] [Full Text] [PDF]
|
|
