![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 16, No. 5, pp. 620-632, March 1, 2002
1 Program in Molecular Medicine and Cell Biology,
2 Howard Hughes Medical Institute, University of Massachusetts
Cancer Center, Worcester, Massachusetts 01605, USA; 3 Division
of Signal Transduction, Graduate School of Biological Sciences, Nara
Institute of Science and Technology, Ikoma, Nara 630-0101, Japan;
4 Department of Cell Pharmacology, Nagoya University, Graduate
School of Medicine, Showa, Nagoya, Aichi 466-8550, Japan
During body morphogenesis precisely coordinated cell movements and
cell shape changes organize the newly differentiated cells of an embryo
into functional tissues. Here we describe two genes, gex-2 and
gex-3, whose activities are necessary for initial steps of body
morphogenesis in Caenorhabditis elegans. In the absence of
gex-2 and gex-3 activities, cells differentiate
properly but fail to become organized. The external hypodermal cells
fail to spread over and enclose the embryo and instead cluster on the dorsal side. Postembryonically gex-3 activity is required for egg laying and for proper morphogenesis of the gonad. GEX-2 and GEX-3
proteins colocalize to cell boundaries and appear to directly interact.
GEX-2 and GEX-3 are highly conserved, with vertebrate homologs
implicated in binding the small GTPase Rac and a GEX-3 Drosophila homolog, HEM2/NAP1/KETTE, that interacts genetically with Rac pathway mutants. Our findings suggest that GEX-2 and GEX-3 may
function at cell boundaries to regulate cell migrations and cell shape
changes required for proper morphogenesis and development.
[Key Words: Epidermal morphogenesis; cell migration; tissue formation; C. elegans]
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Yang, J. Lu, J. Rovnak, S. L. Quackenbush, and E. A. Lundquist SWAN-1, a Caenorhabditis elegans WD Repeat Protein of the AN11 Family, Is a Negative Regulator of Rac GTPase Function Genetics, December 1, 2006; 174(4): 1917 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Mercer, R. K. Miller, T. L. Tinley, S. Sheth, H. Qadota, and G. M. Benian Caenorhabditis elegans UNC-96 Is a New Component of M-Lines That Interacts with UNC-98 and Paramyosin and Is Required in Adult Muscle for Assembly and/or Maintenance of Thick Filaments Mol. Biol. Cell, September 1, 2006; 17(9): 3832 - 3847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Rakeman and K. V. Anderson Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching Development, August 15, 2006; 133(16): 3075 - 3083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Shakir, J. S. Gill, and E. A. Lundquist Interactions of UNC-34 Enabled With Rac GTPases and the NIK Kinase MIG-15 in Caenorhabditis elegans Axon Pathfinding and Neuronal Migration Genetics, February 1, 2006; 172(2): 893 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Denholm, S. Brown, R. P. Ray, M. Ruiz-Gomez, H. Skaer, and J. C.-G. Hombria crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis Development, May 15, 2005; 132(10): 2389 - 2400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-E. Govek, S. E. Newey, and L. Van Aelst The role of the Rho GTPases in neuronal development Genes & Dev., January 1, 2005; 19(1): 1 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grove, G. Demyanenko, A. Echarri, P. A. Zipfel, M. E. Quiroz, R. M. Rodriguiz, M. Playford, S. A. Martensen, M. R. Robinson, W. C. Wetsel, et al. Abi2-Deficient Mice Exhibit Defective Cell Migration, Aberrant Dendritic Spine Morphogenesis, and Deficits in Learning and Memory Mol. Cell. Biol., December 15, 2004; 24(24): 10905 - 10922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, K. Sorefan, G. Hemmann, and M. W. Bevan Arabidopsis NAP and PIR Regulate Actin-Based Cell Morphogenesis and Multiple Developmental Processes Plant Physiology, November 1, 2004; 136(3): 3616 - 3627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Schroter, S. Lier, A. Holz, S. Bogdan, C. Klambt, L. Beck, and R. Renkawitz-Pohl kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila Development, September 15, 2004; 131(18): 4501 - 4509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Basu, S. E.-D. El-Assal, J. Le, E. L. Mallery, and D. B. Szymanski Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development Development, September 1, 2004; 131(17): 4345 - 4355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Brembu, P. Winge, M. Seem, and A. M. Bones NAPP and PIRP Encode Subunits of a Putative Wave Regulatory Protein Complex Involved in Plant Cell Morphogenesis PLANT CELL, September 1, 2004; 16(9): 2335 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Cox and J. Hardin Sticky worms: adhesion complexes in C. elegans J. Cell Sci., April 15, 2004; 117(10): 1885 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Salazar, A. V. Kwiatkowski, L. Pellegrini, G. Cestra, M. H. Butler, K. L. Rossman, D. M. Serna, J. Sondek, F. B. Gertler, and P. De Camilli Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton J. Biol. Chem., December 5, 2003; 278(49): 49031 - 49043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bogdan and C. Klambt Kette regulates actin dynamics and genetically interacts with Wave and Wasp Development, September 15, 2003; 130(18): 4427 - 4437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sawa, S. Suetsugu, A. Sugimoto, H. Miki, M. Yamamoto, and T. Takenawa Essential role of the C. elegans Arp2/3 complex in cell migration during ventral enclosure J. Cell Sci., April 15, 2003; 116(8): 1505 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Struckhoff and E. A. Lundquist The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C. elegans Development, February 15, 2003; 130(4): 693 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Gourley, S. B. Parker, B. J. Jones, K. B. Zumbrennen, and E. A. Leibold Cytosolic Aconitase and Ferritin Are Regulated by Iron in Caenorhabditis elegans J. Biol. Chem., January 24, 2003; 278(5): 3227 - 3234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Miller, P. J. Ruest, M. Kosinski, S. K. Hanks, and D. Greenstein An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans Genes & Dev., January 15, 2003; 17(2): 187 - 200. [Abstract] [Full Text] [PDF]
|
|
