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Vol. 16, No. 8, pp. 908-912, April 15, 2002
1 Department of Clinical Molecular Medicine, Division of
Diabetes, Digestive and Kidney Diseases, Kobe University Graduate
School of Medicine, Chuo-ku, Kobe 650-0017, Japan;
2 Department of Genetic Biochemistry, Kyoto University
Graduate School of Pharmaceutical Sciences, Kyoto 606-8501, Japan;
3 Department of Biochemistry and Molecular Physiology,
University of Occupational and Environmental Health, School of
Medicine, Kitakyushyu 807-8555, Japan; 4 Institute of
Molecular and Cellular Biosciences, University of Tokyo, Tokyo
113-0032, Japan
Fibroblast growth factors (FGFs) are important intercellular
signaling molecules in developmental processes. Here, we show that
FGF10 is secreted by cultured preadipocytes and that prevention of
FGF10 signaling inhibits the expression of C/EBP
and the subsequent differentiation of these cells. An active form of C/EBP rescued differentiation of the cells in which FGF10 signaling was blocked. Development of white adipose tissue and the expression of C/EBP in
this tissue of FGF10 knockout mice were markedly reduced, and the
ability of embryonic fibroblasts derived from FGF10 knockout mice to
differentiate into adipocytes was impaired. Therefore, FGF10 plays an
important role in adipogenesis, at least partly by contributing to the
expression of C/EBP through an autocrine/paracrine mechanism.
[Key Words:
FGF10; adipogenesis; differentiation; C/EBP]
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