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Vol. 17, No. 10, pp. 1219-1224, May 15, 2003
-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice
1 Departments of Human Genetics, 2 Internal
Medicine, 3 Dermatology, and 4 Pathology, and the
5 Cancer Center, University of Michigan School of Medicine,
Ann Arbor, Michigan 48109, USA
Wnts have key roles in many developmental processes, including
hair follicle growth and differentiation. Stabilization of 
-catenin
is essential in the canonical Wnt signaling pathway. We developed
transgenic mice expressing a regulated form of -catenin in the skin.
Chronic activation of -catenin in resting (telogen) hair follicles
resulted in changes consistent with induction of an exaggerated,
aberrant growth phase (anagen). Transient activation of -catenin
produced a normal anagen. Our data lend strong support to the notion
that a Wnt/-catenin signal operating on hair follicle precursor
cells serves as a crucial proximal signal for the telogen-anagen transition.
[Keywords:
-catenin; hair follicle; transgenic mouse; anagen; hair cycle]
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