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RESEARCH COMMUNICATION
1 Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1250, USA , 2 Department of Physiology and Biophysics, Center for Neuroscience, University at Buffalo, New York 14214, USA , 3 SRA International, Inc., Rockville, Maryland 20852, USA
Sequestration of the transcriptional coactivator CREB-binding protein (CBP), a histone acetyltransferase, has been implicated in the pathogenesis of polyglutamine expansion neurodegenerative disease. We used a Drosophila model to demonstrate that polyglutamine-induced neurodegeneration is accompanied by a defect in histone acetylation and a substantial alteration in the transcription profile. Furthermore, we demonstrate complete functional and morphological rescue by up-regulation of endogenous Drosophila CBP (dCBP). Rescue of the degenerative phenotype is associated with eradication of polyglutamine aggregates, recovery of histone acetylation, and normalization of the transcription profile. These findings suggest that histone acetylation is an early target of polyglutamine toxicity and indicate that transcriptional dysregulation is an important part of the pathogenesis of polyglutamine-induced neurodegeneration.
[Keywords: Polyglutamine; Drosophila; CREB-binding protein (CBP); histone acetylation; gene expression analysis; retinal degeneration]
Received February 21, 2003; revised version accepted April 24, 2003.
4 E-MAIL mink{at}ninds.nih.gov; FAX (301) 480-3365.
Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1087503.
Supplemental material is available at http://www.genesdev.org.
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