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Vol. 17, No. 5, pp. 597-602, March 1, 2003

RESEARCH COMMUNICATION
Retraction of the Drosophila germ band requires cell-matrix interaction

Frieder Schöck,1 and Norbert Perrimon2

Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA

Integrins and laminins are important mediators of cell-matrix interactions in both vertebrates and invertebrates. Here, we show that germ-band retraction in the Drosophila embryo, during which the tail end of the embryo retracts to its final posterior position, allows the investigation of cell spreading and lamellipodia formation in real time in vivo. We demonstrate that alpha 1, 2 laminin and alpha PS3beta PS integrin are required for the spreading of a small group of cells of the amnioserosa epithelium over the tail end of the germ band. We further implicate a role for this spreading in the process of germ-band retraction.

[Keywords: Cell spreading; Drosophila; germ-band retraction; integrin; laminin]

1 E-MAIL fschoeck{at}genetics.med.harvard.edu; FAX (617) 432-7688.

2 E-MAIL perrimon{at}rascal.med.harvard.edu; FAX (617) 432-7688.

© 2003 by Cold Spring Harbor Laboratory Press  ISSN 0890-9369/03 $5.00
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