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RESEARCH COMMUNICATION
1 Program in Developmental Biology and 2 Departments of Molecular and Cellular Biology and 3 Dermatology, Baylor College of Medicine, Houston, Texas 77030, USA; 4 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (
N) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by Np63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratinocytes in mature epidermis.
[Keywords: p63; stratified epithelia; molecular switch; embryogenesis; terminal differentiation; proliferative potential]
Received October 28, 2003; revised version accepted December 1, 2003.
5 Corresponding author. E-MAIL roopd{at}bcm.tmc.edu; FAX (713) 798-3800.
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