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REVIEW

A systems view of mRNP biology

Department of Systems Biology, Harvard Medical School and the Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA

Gene expression occurs through a complex mRNA-protein (mRNP) system that stretches from transcription to translation. Gene expression processes are increasingly studied from global perspectives in order to understand their pathways, properties, and behaviors as a system. Here we review these beginnings of mRNP systems biology, as they have emerged from recent large-scale investigation of mRNP components, interactions, and dynamics. Such work has begun to lay the foundation for a broader, integrated view of mRNP organization in gene expression.

[Keywords: Systems biology; messenger ribonucleoprotein complexes; mRNP; genomics; mRNA decay; mRNA transport; translation; splicing]

¹ Corresponding author.
E-MAIL Pamela_silver{at}dfci.harvard.edu; FAX (617) 632-5103.

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