Genes and Development

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

GENES & DEVELOPMENT 18:739-744, 2004
©2004 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bemis, L.
Right arrow Articles by Zundel, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bemis, L.
Right arrow Articles by Zundel, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

RESEARCH COMMUNICATION

Distinct aerobic and hypoxic mechanisms of HIF-{alpha} regulation by CSN5

Lynne Bemis1, Denise A. Chan4,5, Carla V. Finkielstein2, Lin Qi3, Patrick D. Sutphin4,5, Xiaojiang Chen2, Kurt Stenmark1, Amato J. Giaccia4,5 and Wayne Zundel6,7,8

Departments of 1 Medicine and 2 Biochemistry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA; 3 Division of Urology, Xiangya Hospital, Changsha, P.R. China; 4 Program in Cancer Biology and 5 Department of Radiation Oncology, Stanford University, Stanford, California 94303, USA; 6 Department of Radiation Oncology and 7 Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA

Mammalian oxygen homeostasis is dependent on the HIF family of transcription factors. The CSN subunit, CSN5, binds both the CODD of HIF-1{alpha} and the pVHL tumor suppressor. High CSN5 expression generates a pVHL-independent form of CSN5 that stabilizes HIF-1{alpha} aerobically by inhibiting HIF-1{alpha} prolyl-564 hydroxylation. Aerobic CSN5 association with HIF-1{alpha} occurs independently of the CSN holocomplex, leading to HIF-1{alpha} stabilization independent of Cullin 2 deneddylation. CSN5 weakly associates with HIF-1{alpha} under hypoxia, but is required for optimal hypoxia-mediated HIF-1{alpha} stabilization. These results indicate that CSN5 regulates aerobic as well as hypoxic HIF-1{alpha} stability by different mechanisms during oncogenesis.

[Keywords: Von Hippel-Lindau; COP9 signalosome; hypoxia inducible factor-1{alpha}]

Received December 18, 2003; revised version accepted March 1, 2004.

Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1180104.

Corresponding author.

8 E-MAIL Wayne.Zundel{at}uchsc.edu; FAX (303) 315-8825.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. Miyauchi, M. Kato, F. Tokunaga, and K. Iwai
The COP9/Signalosome Increases the Efficiency of von Hippel-Lindau Protein Ubiquitin Ligase-mediated Hypoxia-inducible Factor-{alpha} Ubiquitination
J. Biol. Chem., June 13, 2008; 283(24): 16622 - 16631.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. S. Adler, L. E. Littlepage, M. Lin, T. L.A. Kawahara, D. J. Wong, Z. Werb, and H. Y. Chang
CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression
Cancer Res., January 15, 2008; 68(2): 506 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Winner, A. C. Koong, B. E. Rendon, W. Zundel, and R. A. Mitchell
Amplification of Tumor Hypoxic Responses by Macrophage Migration Inhibitory Factor-Dependent Hypoxia-Inducible Factor Stabilization
Cancer Res., January 1, 2007; 67(1): 186 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. M. Mense, A. Sengupta, M. Zhou, C. Lan, G. Bentsman, D. J. Volsky, and L. Zhang
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes
Physiol Genomics, May 16, 2006; 25(3): 435 - 449.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. N. de Jong, E. AB, T. Diercks, V. Truffault, M. Daniels, R. Kaptein, and G. E. Folkers
Solution Structure of the Human Ubiquitin-specific Protease 15 DUSP Domain
J. Biol. Chem., February 24, 2006; 281(8): 5026 - 5031.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
K. S. Richardson and W. Zundel
The Emerging Role of the COP9 Signalosome in Cancer
Mol. Cancer Res., December 1, 2005; 3(12): 645 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
R. H. Wenger, D. P. Stiehl, and G. Camenisch
Integration of Oxygen Signaling at the Consensus HRE
Sci. Signal., October 18, 2005; 2005(306): re12 - re12.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. A. Chan, P. D. Sutphin, S.-E. Yen, and A. J. Giaccia
Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1{alpha}
Mol. Cell. Biol., August 1, 2005; 25(15): 6415 - 6426.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Tomoda, N. Yoneda-Kato, A. Fukumoto, S. Yamanaka, and J.-y. Kato
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice
J. Biol. Chem., October 8, 2004; 279(41): 43013 - 43018.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. J. Giaccia, M. C. Simon, and R. Johnson
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Genes & Dev., September 15, 2004; 18(18): 2183 - 2194.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Genome Res. Learn. Mem.
Protein Science RNA Genes Dev.
Copyright © 2004 by Cold Spring Harbor Laboratory Press.