![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
RESEARCH COMMUNICATION
1 Laboratory of Molecular Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland 20814, USA; 2 Department of Anatomy, Institute of Biomedical Research, University of Birmingham, Edgbaston B15 2TT, United Kingdom; 3 Department of Biology and Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana 47405, USA; 4 Whitehead Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Drosophila NURF is an ISWI-containing ATP-dependent chromatin remodeling complex that regulates transcription by catalyzing nucleosome sliding. To determine in vivo gene targets of NURF, we performed whole genome expression analysis on mutants lacking the NURF-specific subunit NURF301. Strikingly, a large set of ecdysone-responsive targets is included among several hundred NURF-regulated genes. Null Nurf301 mutants do not undergo larval to pupal metamorphosis, and also enhance dominant-negative mutations in ecdysone receptor. Moreover, purified NURF binds EcR in an ecdysone-dependent manner, suggesting it is a direct effector of nuclear receptor activity. The conservation of NURF in mammals has broad implications for steroid signaling.
[Keywords: NURF; chromatin remodeling; chromatin; Drosophila; Ecdysteroid; ISWI]
Received June 9, 2005; revised version accepted August 26, 2005.
Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.1342605.
6 E-MAIL p.w.badenhorst{at}bham.ac.uk; FAX 44-121-414-3599.
5 E-MAIL carlwu{at}helix.nih.gov; FAX (301) 435-3697.
Related Article
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Genes & Dev. 2006 20: 2779-2786.
This article has been cited by other articles:
|
|
 |
|
  X. Bai, E. Larschan, S. Y. Kwon, P. Badenhorst, and M. I. Kuroda Regional Control of Chromatin Organization by Noncoding roX RNAs and the NURF Remodeling Complex in Drosophila melanogaster Genetics, July 1, 2007; 176(3): 1491 - 1499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yang, C. Zheng, and J. J. Hayes The Core Histone Tail Domains Contribute to Sequence-dependent Nucleosome Positioning J. Biol. Chem., March 16, 2007; 282(11): 7930 - 7938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhu, L. Chen, G. Sun, and A. S. Raikhel The Competence Factor {beta}Ftz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator Mol. Cell. Biol., December 15, 2006; 26(24): 9402 - 9412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Zraly, F. A. Middleton, and A. K. Dingwall Hormone-response Genes Are Direct in Vivo Regulatory Targets of Brahma (SWI/SNF) Complex Function J. Biol. Chem., November 17, 2006; 281(46): 35305 - 35315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Sims III and D. Reinberg Histone H3 Lys 4 methylation: caught in a bind? Genes & Dev., October 15, 2006; 20(20): 2779 - 2786. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Stabell, R. Eskeland, M. Bjorkmo, J. Larsson, R. B. Aalen, A. Imhof, and A. Lambertsson The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development Nucleic Acids Res., September 11, 2006; 34(16): 4609 - 4621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Rosenfeld, V. V. Lunyak, and C. K. Glass Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response Genes & Dev., June 1, 2006; 20(11): 1405 - 1428. [Abstract] [Full Text] [PDF]
|
|
