QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Reearch Data All Versions of this Article: gad.1561307v1 21/13/1598    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Geldner, N. Articles by Chory, J. Search for Related Content PubMed PubMed Citation Articles by Geldner, N. Articles by Chory, J. Related Content Related Article Social Bookmarking                   What's this?

RESEARCH COMMUNICATION

Endosomal signaling of plant steroid receptor kinase BRI1

¹ Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA; ² Howard Hughes Medical Institute Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA; ³ Zentrum für Molekularbiologie der Pflanzen, 72076 Tübingen, Germany

The LRR receptor serine/threonine kinases are a major eukaryotic receptor family, for which the central regulatory mechanism of endosomal trafficking remains largely unadressed. We show that the steroid receptor BRI1 localizes to both plasma membrane and early endosomal compartments, even when observed at low, endogenous expression levels, and that its localization and turnover are independent of ligand. However, increasing endosomal localization of BRI1 enhances activation of the pathway and genomic responses. Our data indicate distinct signaling and trafficking mechanisms within this receptor class and show that the use of endosomes as signaling compartments is an unexpectedly broad phenomenon in eukaryotes.

[Keywords: Brassinosteroid; endosomes; plant receptor kinase; Arabidopsis; receptor trafficking]

Received April 12, 2007; revised version accepted May 16, 2007.

E-MAIL chory{at}salk.edu; FAX (858) 558-6379.

Supplemental material is available at http://www.genesdev.org.

Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.1561307

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Signaling from plant endosomes: compartments with something to say!

Natasha Raikhel and Glenn Hicks
Genes & Dev. 2007 21: 1578-1580. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				S. Robert, S. N. Chary, G. Drakakaki, S. Li, Z. Yang, N. V. Raikhel, and G. R. Hicks Endosidin1 defines a compartment involved in endocytosis of the brassinosteroid receptor BRI1 and the auxin transporters PIN2 and AUX1 PNAS, June 17, 2008; 105(24): 8464 - 8469. [Abstract] [Full Text] [PDF]

				N. Leborgne-Castel, J. Lherminier, C. Der, J. Fromentin, V. Houot, and F. Simon-Plas The Plant Defense Elicitor Cryptogein Stimulates Clathrin-Mediated Endocytosis Correlated with Reactive Oxygen Species Production in Bright Yellow-2 Tobacco Cells Plant Physiology, March 1, 2008; 146(3): 1255 - 1266. [Abstract] [Full Text] [PDF]

				G. S. Ali, K. V. S. K. Prasad, I. Day, and A. S. N. Reddy Ligand-Dependent Reduction in the Membrane Mobility of FLAGELLIN SENSITIVE2, an Arabidopsis Receptor-Like Kinase Plant Cell Physiol., November 1, 2007; 48(11): 1601 - 1611. [Abstract] [Full Text] [PDF]

				N. Raikhel and G. Hicks Signaling from plant endosomes: compartments with something to say! Genes & Dev., July 1, 2007; 21(13): 1578 - 1580. [Full Text] [PDF]