Genes and Development

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GENES & DEVELOPMENT 21:2258-2270, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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HISTORICAL PERSPECTIVE

The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer

Douglas Hanahan1,4, Erwin F. Wagner2, and Richard D. Palmiter3

1 Department of Biochemistry and Biophysics, Diabetes Center, and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA; 2 Research Institute for Molecular Pathology (IMP), Vienna A-1030, Austria; 3 Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA

This perspective describes the concurrent development in the 1980s of the first transgenic mice genetically engineered to express dominant oncogenes, involving independent researchers who were largely unaware of each other’s strategies and progress. We relate the experimental designs, the pitfalls and challenges encountered, and the eventual success in developing distinctive mouse models of cancer, wherein tumors arose heritably in various organs. These early oncomice have produced a wealth of new knowledge, become topics of intellectual property, and spawned a vibrant field of cancer research that is revealing mechanisms of tumorigenesis and suggesting new therapeutic strategies for treating the human disease.

[Keywords: Transgenic mice; mouse models of human cancer; oncogenes; tumors; oncomouse patents]

4 Corresponding author.

E-MAIL dh{at}biochem.ucsf.edu; FAX (415) 731-3612.

Supplemental material is available at http://www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1583307


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