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GENES & DEVELOPMENT 21:391-396, 2007
©2007 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest

Yun Kee1,3, Byung Joon Hwang1,2,3, Paul W. Sternberg1,2, and Marianne Bronner-Fraser1,4

1 Division of Biology, California Institute of Technology, Pasadena, California 91125, USA; 2 Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA

Because migratory cells in all animals share common properties, we hypothesized that genetic networks involved in cell migration may be conserved between nematodes and vertebrates. To explore this, we performed comparative genomic analysis to identify vertebrate orthologs of genes required for hermaphrodite-specific neuron (HSN) migration in Caenoryhabditis elegans, and then examined their expression and function in the vertebrate neural crest. The results demonstrate high conservation of regulatory components involved in long-range migrations across diverse species. Although the neural crest is a vertebrate innovation, the results suggest that its migratory properties evolved by utilizing programs already present in the common vertebrate–invertebrate ancestor.

[Keywords: Neural crest; cell migration; C. elegans HSN; comparative genomic analysis]

Received November 7, 2006; revised version accepted January 9, 2007.

3 These authors contributed equally to this work.

4 Corresponding author.

E-MAIL mbronner{at}caltech.edu; FAX (626) 395-7717.

Supplemental material is available at http://www.genesdev.org

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1509307


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