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GENES & DEVELOPMENT 22:740-745, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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RESEARCH COMMUNICATION

Cooperative regulation in development by SMRT and FOXP1

Kristen Jepsen1,5, Anatoli S. Gleiberman2, Can Shi3, Daniel I. Simon3, and Michael G. Rosenfeld1,4

1 Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA; 2 Cleveland Biolabs, Inc., Buffalo, New York 14052, USA; 3 University Hospitals Case Medical Center, Case Western Reserve University School of Medicine. Cleveland, Ohio 44106, USA

A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination events. While the role of NCoR/SMRT corepressors in nuclear receptor actions is well documented, we here report that a previously unrecognized functional interaction between SMRT and a forkhead protein, FOXP1, is required for cardiac growth and regulation of macrophage differentiation. Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor.

[Keywords: SMRT; FOXP1; corepressor; heart; macrophage]]

Received November 27, 2007; revised version accepted January 18, 2008.

4 Corresponding authors.

E-MAIL mrosenfeld{at}ucsd.edu; FAX (858) 534-8180.

5 E-MAIL jepsen{at}ucsd.edu; FAX (858) 534-8180.

Supplemental material is available at http://www.genesdev.org.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1637108.


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