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Semaphorin signaling in morphogenesis: found in translation

Division of Biological Sciences, Section of Neurobiology, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, California 92093, USA

Semaphorins play diverse roles in axon guidance and epithelial morphogenetic cell movements. In this issue of Genes & Development, Nukazuka and colleagues (1025–1036) show that semaphorins regulate Caenorhabditis elegans male tail morphogenesis by stimulating the translation of specific messages, including the actin-depolymerizing enzyme cofilin.

[Keywords: C. elegans; cofilin; eIF2; epidermal morphogenesis; mRNA translation; semaphorin]]

E-MAIL chisholm{at}ucsd.edu; FAX (858) 534-7773.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1669308.

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Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2 in Caenorhabditis elegans

Akira Nukazuka, Hajime Fujisawa, Toshifumi Inada, Yoichi Oda, and Shin Takagi
Genes & Dev. 2008 22: 1025-1036. [Abstract] [Full Text] [PDF]