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GENES & DEVELOPMENT 22:960-963, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase

Tomomasa Yokomizo and Elaine Dzierzak1

Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands

Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992–997) report a new player in HSC homeostasis, c-Cbl ubiq-uitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.

[Keywords: Hematopoietic stem cells; c-Cbl; thrombopoietin; STAT5; self-renewal]]

1 Corresponding author.

E-MAIL e.dzierzak{at}erasmusmc.nl; FAX 31-10-704-4468.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1669908.


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Related Article

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
Chozhavendan Rathinam, Christine B.F. Thien, Wallace Y. Langdon, Hua Gu, and Richard A. Flavell
Genes & Dev. 2008 22: 992-997. [Abstract] [Full Text] [PDF]





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