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PERSPECTIVE

pRb and condensin—local control of global chromosome structure

Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011–1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates the Rb family proteins in mitotic chromosome condensation and suggests that a failure in targeting condensin II to chromatin underlies the aneuploidy in rbf1 mutants.

[Keywords: RBF1; RB; CAP-D3; chromatin; condensation; Condensin II]]

E-MAIL brigitte.lavoie{at}utoronto.ca; FAX (416) 978-6885.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1666808.

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Related Article

RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

Michelle S. Longworth, Anabel Herr, Jun-Yuan Ji, and Nicholas J. Dyson
Genes & Dev. 2008 22: 1011-1024. [Abstract] [Full Text] [PDF]