Genes and Development

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GENES & DEVELOPMENT 22:970-975, 2008
©2008 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Small RNA guides for de novo DNA methylation in mammalian germ cells

Alexei A. Aravin1 and Déborah Bourc’his2,3

1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; 2 Institut National de la Santé et de la Recherche Médicale (INSERM) U741/Paris 7 University, 75251 Paris Cedex 05, France

Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (908–917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.

[Keywords: Piwi; piRNA; retrotransposon; DNA methylation; spermatogenesis]]

3 Corresponding author.

E-MAIL bourchis{at}ijm.jussieu.fr; FAX 33-1-44-27-82-10.

Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1669408.


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Related Article

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Genes & Dev. 2008 22: 908-917. [Abstract] [Full Text] [PDF]





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