![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
Abstract
A Drosophila strain was isolated that carries a lacZ-bearing recombinant P element integrated in the cubitus interruptus Dominant (ci-D) locus. This strain expresses beta-galactosidase in the anterior compartments of embryos and imaginal discs, suggesting that expression of ci-D is anterior-compartment specific. DNA from ci-D was cloned. In situ hybridization to imaginal discs confirmed that ci-D RNA is present only in anterior compartments. ci-D RNA is also limited to the anterior compartments at the germ-band extension stage of embryonic development, although not at earlier stages. In engrailed mutants, ci-D expression was derepressed in the posterior compartments of both embryos and imaginal discs. We postulate that engrailed, which is expressed in only the posterior compartments of embryos and imaginal discs, represses ci-D in these cells.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Wehn and G. Campbell Genetic Interactions Among scribbler, Atrophin and groucho in Drosophila Uncover Links in Transcriptional Repression Genetics, June 1, 2006; 173(2): 849 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Ayoob, J. R. Terman, and A. L. Kolodkin Drosophila Plexin B is a Sema-2a receptor required for axon guidance Development, June 1, 2006; 133(11): 2125 - 2135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Cooper, K. P. Yu, M. Brueckner, L. L. Brailey, L. Johnson, J. M. McGrath, and A. E. Bale Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused Development, October 1, 2005; 132(19): 4407 - 4417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Hatini, R. B. Green, J. A. Lengyel, S. J. Bray, and S. DiNardo The Drumstick/Lines/Bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation Genes & Dev., March 15, 2005; 19(6): 709 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, E. H. Williams, Y. Guo, L. Lum, and P. A. Beachy Inaugural Article: Extensive phosphorylation of Smoothened in Hedgehog pathway activation PNAS, December 28, 2004; 101(52): 17900 - 17907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bushey and J. Locke Mutations in Su(var)205 and Su(var)3-7 Suppress P-Element-Dependent Silencing in Drosophila melanogaster Genetics, November 1, 2004; 168(3): 1395 - 1411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Larsen, E. Hirst, C. Alexandre, and J.-P. Vincent Segment boundary formation in Drosophila embryos Development, December 1, 2003; 130(23): 5625 - 5635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Lee, K. Amanai, A. Shearn, and J. E. Treisman The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms Development, March 14, 2003; 129(24): 5697 - 5706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Micchelli, I. The, E. Selva, V. Mogila, and N. Perrimon rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling Development, March 4, 2003; 129(4): 843 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kobayashi, M. Fujioka, E. N. Tolkunova, D. Deka, M. Abu-Shaar, R. S. Mann, and J. B. Jaynes Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila Development, February 15, 2003; 130(4): 741 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Maurange and R. Paro A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development Genes & Dev., October 15, 2002; 16(20): 2672 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Ou, Y.-F. Lin, Y.-J. Chen, and C.-T. Chien Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development Genes & Dev., September 15, 2002; 16(18): 2403 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Nybakken, C. W. Turck, D. J. Robbins, and J. M. Bishop Hedgehog-stimulated Phosphorylation of the Kinesin-related Protein Costal2 Is Mediated by the Serine/Threonine Kinase Fused J. Biol. Chem., June 28, 2002; 277(27): 24638 - 24647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ascano Jr., K. E. Nybakken, J. Sosinski, M. A. Stegman, and D. J. Robbins The Carboxyl-Terminal Domain of the Protein Kinase Fused Can Function as a Dominant Inhibitor of Hedgehog Signaling Mol. Cell. Biol., March 1, 2002; 22(5): 1555 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bai and D. Montell Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis Development, January 12, 2002; 129(23): 5377 - 5388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Svendsen, S. Marshall, M Kyba, and W. Brook The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster Development, January 10, 2000; 127(19): 4083 - 4093. [Abstract] [PDF]
|
|
|
|
|
|
G. Campbell and A Tomlinson Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap Development, January 10, 2000; 127(19): 4095 - 4103. [Abstract] [PDF]
|
|
|
|
|
|
T Suzuki and K Saigo Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus Development, January 4, 2000; 127(7): 1531 - 1540. [Abstract] [PDF]
|
|
|
|
 |
|
 D. N. Keys, D. L. Lewis, J. E. Selegue, B. J. Pearson, L. V. Goodrich, R. L. Johnson, J. Gates, M. P. Scott, and S. B. Carroll Recruitment of a hedgehog Regulatory Circuit in Butterfly Eyespot Evolution Science, January 22, 1999; 283(5401): 532 - 534. [Abstract] [Full Text]
|
|
|
|
|
|
Q. Wang and R. Holmgren The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels Development, January 11, 1999; 126(22): 5097 - 5106. [Abstract] [PDF]
|
|
|
|
|
|
P. Therond, B Limbourg Bouchon, A Gallet, F Dussilol, T Pietri, M van den Heuvel, and H Tricoire Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo Development, January 9, 1999; 126(18): 4039 - 4051. [Abstract] [PDF]
|
|
|
|
|
|
R Hays, K. Buchanan, C Neff, and T. Orenic Patterning of Drosophila leg sensory organs through combinatorial signaling by hedgehog, decapentaplegic and wingless Development, January 7, 1999; 126(13): 2891 - 2899. [Abstract] [PDF]
|
|
|
|
|
|
A Amin, Y Li, and R Finkelstein Hedgehog activates the EGF receptor pathway during Drosophila head development Development, January 6, 1999; 126(12): 2623 - 2630. [Abstract] [PDF]
|
|
|
|
|
|
M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development Development, January 11, 1998; 125(22): 4521 - 4530. [Abstract] [PDF]
|
|
|
|
|
|
Z Huang and S Kunes Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly Development, January 10, 1998; 125(19): 3753 - 3764. [Abstract] [PDF]
|
|
|
|
|
|
A Ruiz i Altaba Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog Development, January 6, 1998; 125(12): 2203 - 2212. [Abstract] [PDF]
|
|
|
|
|
|
J. T. Ohlmeyer and D. Kalderon Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos Genes & Dev., September 1, 1997; 11(17): 2250 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Von Ohlen, D. Lessing, R. Nusse, and J. E. Hooper Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein PNAS, March 18, 1997; 94(6): 2404 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N Serrano, H. Brock, and F Maschat beta3-tubulin is directly repressed by the engrailed protein in Drosophila Development, January 7, 1997; 124(13): 2527 - 2536. [Abstract] [PDF]
|
|
|
|
|
|
J Lee, K. Platt, P Censullo, and A Ruiz i Altaba Gli1 is a target of Sonic hedgehog that induces ventral neural tube development Development, January 7, 1997; 124(13): 2537 - 2552. [Abstract] [PDF]
|
|
|
|
|
|
G Struhl, D. Barbash, and P. Lawrence Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen Development, January 6, 1997; 124(11): 2143 - 2154. [Abstract] [PDF]
|
|
|
|
|
|
E. Chen and B. Baker Compartmental organization of the Drosophila genital imaginal discs Development, January 1, 1997; 124(1): 205 - 218. [Abstract] [PDF]
|
|
|
|
|
|
J Hepker, Q. Wang, C. Motzny, R Holmgren, and T. Orenic Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes Development, January 1, 1997; 124(2): 549 - 558. [Abstract] [PDF]
|
|
|
|
|
|
C Alexandre, A Jacinto, and P W Ingham Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes & Dev., August 15, 1996; 10(16): 2003 - 2013. [Abstract] [PDF]
|
|
|
|
|
|
H Theisen, T. Haerry, M. O'Connor, and J. Marsh Developmental territories created by mutual antagonism between Wingless and Decapentaplegic Development, January 12, 1996; 122(12): 3939 - 3948. [Abstract] [PDF]
|
|
|
|
|
|
S. Smith and J. Jaynes A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo Development, January 10, 1996; 122(10): 3141 - 3150. [Abstract] [PDF]
|
|
|
|
|
|
A. Forbes, A. Spradling, P. Ingham, and H Lin The role of segment polarity genes during early oogenesis in Drosophila Development, January 10, 1996; 122(10): 3283 - 3294. [Abstract] [PDF]
|
|
|
|
|
|
R. Johnson, J. Grenier, and M. Scott patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets Development, January 12, 1995; 121(12): 4161 - 4170. [Abstract] [PDF]
|
|
|
|
|
|
T Tabata, C Schwartz, E Gustavson, Z Ali, and T. Kornberg Creating a Drosophila wing de novo, the role of engrailed, and the compartment border hypothesis Development, January 10, 1995; 121(10): 3359 - 3369. [Abstract] [PDF]
|
|
|
|
|
|
J. de Celis and M Ruiz-Gomez groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing Development, January 10, 1995; 121(10): 3467 - 3476. [Abstract] [PDF]
|
|
|
|
|
|
C Schwartz, J Locke, C Nishida, and T. Kornberg Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks Development, January 6, 1995; 121(6): 1625 - 1635. [Abstract] [PDF]
|
|
|
|
|
|
N Serrano, H. Brock, C Demeret, J. Dura, N. Randsholt, T. Kornberg, and F Maschat polyhomeotic appears to be a target of engrailed regulation in Drosophila Development, January 6, 1995; 121(6): 1691 - 1703. [Abstract] [PDF]
|
|
|
|
|
|
A John, S. Smith, and J. Jaynes Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo Development, January 6, 1995; 121(6): 1801 - 1813. [Abstract] [PDF]
|
|
|
|
|
|
K M Cadigan, U Grossniklaus, and W J Gehring Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes & Dev., April 15, 1994; 8(8): 899 - 913. [Abstract] [PDF]
|
|
|
|
|
|
M J Benedyk, J R Mullen, and S DiNardo odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Genes & Dev., January 1, 1994; 8(1): 105 - 117. [Abstract] [PDF]
|
|
|
|
|
|
P. Bryant The polar coordinate model goes molecular Science, January 22, 1993; 259(5094): 471 - 472. [PDF]
|
|
|
|
|
|
S. Blair Mechanisms of compartment formation: evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila Development, January 10, 1993; 119(2): 339 - 351. [Abstract] [PDF]
|
|
|
|
|
|
W. Brook, L. Ostafichuk, J Piorecky, M. Wilkinson, D. Hodgetts, and M. Russell Gene expression during imaginal disc regeneration detected using enhancer-sensitive P-elements Development, January 4, 1993; 117(4): 1287 - 1297. [Abstract] [PDF]
|
|
|
|
|
|
M Van Doren, P A Powell, D Pasternak, A Singson, and J W Posakony Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes & Dev., December 1, 1992; 6(12b): 2592 - 2605. [Abstract] [PDF]
|
|
|
|
|
|
T Tabata, S Eaton, and T B Kornberg The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes & Dev., December 1, 1992; 6(12b): 2635 - 2645. [Abstract] [PDF]
|
|
|
|
|
|
J Noordermeer, P Johnston, F Rijsewijk, R Nusse, and P. Lawrence The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo Development, January 11, 1992; 116(3): 711 - 719. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Stegman, J. E. Vallance, G. Elangovan, J. Sosinski, Y. Cheng, and D. J. Robbins Identification of a Tetrameric Hedgehog Signaling Complex J. Biol. Chem., July 14, 2000; 275(29): 21809 - 21812. [Abstract] [Full Text] [PDF]
|
|
