QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bossy-Wetzel, E Articles by Hanahan, D Search for Related Content PubMed PubMed Citation Articles by Bossy-Wetzel, E Articles by Hanahan, D Social Bookmarking                   What's this?

Research Papers

Transcription factors junB and c-jun are selectively up-regulated and functionally implicated in fibrosarcoma development.

Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0534.

Abstract

Bovine papillomavirus transgenic mice develop skin tumors arising from dermal fibroblasts in a process comprised of three distinctive stages: mild and aggressive fibromatoses, and fibrosarcoma. In both tissue biopsies and derivative cell lines, the proto-oncogenes junB and c-jun are induced in the latter two stages, in contrast to junD and fos. Fibrosarcoma cell lines have increased AP-1 DNA-binding activity. Overexpression of junB or c-jun by transfection into the mild fibromatosis stage elicited changes in cell shape and anchorage independence, whereas junD did not. Similar transfections of normal skin fibroblasts had no effect. Thus, junB and c-jun represent progression factors whose activities are necessary at an intermediate stage of tumor development, subsequent to the initiation of aberrant proliferation.

CiteULike

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				R. Farras, V. Baldin, S. Gallach, C. Acquaviva, G. Bossis, I. Jariel-Encontre, and M. Piechaczyk JunB Breakdown in Mid-/Late G2 Is Required for Down-Regulation of Cyclin A2 Levels and Proper Mitosis Mol. Cell. Biol., June 15, 2008; 28(12): 4173 - 4187. [Abstract] [Full Text] [PDF]

				D. Hanahan, E. F. Wagner, and R. D. Palmiter The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer Genes & Dev., September 15, 2007; 21(18): 2258 - 2270. [Abstract] [Full Text] [PDF]

				A. P. Szremska, L. Kenner, E. Weisz, R. G. Ott, E. Passegue, M. Artwohl, M. Freissmuth, R. Stoxreiter, H.-C. Theussl, S. B. Parzer, et al. JunB inhibits proliferation and transformation in B-lymphoid cells Blood, December 1, 2003; 102(12): 4159 - 4165. [Abstract] [Full Text] [PDF]

				D. M. Gascoyne, R. M. Kypta, and M. d. M. Vivanco Glucocorticoids Inhibit Apoptosis during Fibrosarcoma Development by Transcriptionally Activating Bcl-xL J. Biol. Chem., May 9, 2003; 278(20): 18022 - 18029. [Abstract] [Full Text] [PDF]

				D. J. Toft, S. B. Rosenberg, G. Bergers, O. Volpert, and D. I. H. Linzer Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression PNAS, October 16, 2001; (2001) 231364798. [Abstract] [Full Text] [PDF]

				D. A. Elson, H. E. Ryan, J. W. Snow, R. Johnson, and J. M. Arbeit Coordinate Up-Regulation of Hypoxia Inducible Factor (HIF)-1{{alpha}} and HIF-1 Target Genes during Multi-Stage Epidermal Carcinogenesis and Wound Healing Cancer Res., November 1, 2000; 60(21): 6189 - 6195. [Abstract] [Full Text]

				L. M. Coussens, W. W. Raymond, G. Bergers, M. Laig-Webster, O. Behrendtsen, Z. Werb, G. H. Caughey, and D. Hanahan Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis Genes & Dev., June 1, 1999; 13(11): 1382 - 1397. [Abstract] [Full Text]

				A. R. Patel and J.-Y. Wang Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells Am J Physiol Gastrointest Liver Physiol, February 1, 1999; 276(2): G441 - G450. [Abstract] [Full Text] [PDF]

				R S Johnson, B van Lingen, V E Papaioannou, and B M Spiegelman A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes & Dev., July 1, 1993; 7(7b): 1309 - 1317. [Abstract] [PDF]

				D. J. Toft, S. B. Rosenberg, G. Bergers, O. Volpert, and D. I. H. Linzer Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression PNAS, November 6, 2001; 98(23): 13055 - 13059. [Abstract] [Full Text] [PDF]