.gif?ad=16248&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618.
Abstract
The human salivary amylase genes are associated with two inserted elements, a gamma-actin-processed pseudogene and an endogenous retroviral-like element. To test the contribution of these inserted elements to tissue specificity, 25 lines of transgenic mice carrying 10 amylase constructs were established. A 1-kb fragment of AMY1C (-1003 to +2) was found to be sufficient for parotid-specific expression of a human growth hormone reporter gene. The 1-kb fragment is entirely derived from inserted sequences. Deletion from -1003 to -826 resulted in reduced levels of transgene expression and loss of tissue specificity. The fragment -1003 to -327 was sufficient to transfer parotid specificity to the thymidine kinase promoter. The data demonstrate that the functional tissue-specific promoter of human AMY1C is derived from inserted sequences and that parotid expression can be conferred by sequences derived solely from the retrovirus. A role for retrotransposition in the evolution of gene regulation is indicated by these and other recent observations.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Katzourakis, V. Pereira, and M. Tristem Effects of Recombination Rate on Human Endogenous Retrovirus Fixation and Persistence J. Virol., October 1, 2007; 81(19): 10712 - 10717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-S. Wang, Z. Zhang, H.-C. Wang, J.-L. Cai, Q.-W. Xu, M.-Q. Li, Y.-C. Chen, X.-P. Qian, T.-J. Lu, L.-Z. Yu, et al. Rapid Identification of UCA1 as a Very Sensitive and Specific Unique Marker for Human Bladder Carcinoma. Clin. Cancer Res., August 15, 2006; 12(16): 4851 - 4858. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yu, X. Zhu, W. Pi, J. Ling, L. Ko, Y. Takeda, and D. Tuan The Long Terminal Repeat (LTR) of ERV-9 Human Endogenous Retrovirus Binds to NF-Y in the Assembly of an Active LTR Enhancer Complex NF-Y/MZF1/GATA-2 J. Biol. Chem., October 21, 2005; 280(42): 35184 - 35194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jern, G. O. Sperber, G. Ahlsen, and J. Blomberg Sequence Variability, Gene Structure, and Expression of Full-Length Human Endogenous Retrovirus H J. Virol., May 15, 2005; 79(10): 6325 - 6337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Prudhomme, G. Oriol, and F. Mallet A Retroviral Promoter and a Cellular Enhancer Define a Bipartite Element Which Controls env ERVWE1 Placental Expression J. Virol., November 15, 2004; 78(22): 12157 - 12168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Palmarini, M. Mura, and T. E. Spencer Endogenous betaretroviruses of sheep: teaching new lessons in retroviral interference and adaptation J. Gen. Virol., January 1, 2004; 85(1): 1 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Squire and M. T. Andrews Pancreatic triacylglycerol lipase in a hibernating mammal. I. Novel genomic organization Physiol Genomics, December 16, 2003; 16(1): 119 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-R. Landry and D. L. Mager Functional Analysis of the Endogenous Retroviral Promoter of the Human Endothelin B Receptor Gene J. Virol., July 1, 2003; 77(13): 7459 - 7466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-R. Landry, A. Rouhi, P. Medstrand, and D. L. Mager The Opitz Syndrome Gene Mid1 Is Transcribed from a Human Endogenous Retroviral Promoter Mol. Biol. Evol., November 1, 2002; 19(11): 1934 - 1942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Mitchem, E. Hibbard, L. A. Beyer, K. Bosom, G. A. Dootz, D. F. Dolan, K. R. Johnson, Y. Raphael, and D. C. Kohrman Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6 Hum. Mol. Genet., August 1, 2002; 11(16): 1887 - 1898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ling, W. Pi, R. Bollag, S. Zeng, M. Keskintepe, H. Saliman, S. Krantz, B. Whitney, and D. Tuan The Solitary Long Terminal Repeats of ERV-9 Endogenous Retrovirus Are Conserved during Primate Evolution and Possess Enhancer Activities in Embryonic and Hematopoietic Cells J. Virol., March 1, 2002; 76(5): 2410 - 2423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. W. Bauer, T. L. Squire, M. E. Lowe, and M. T. Andrews Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1186 - R1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jeyaseelan, A. Armugam, M. Donghui, and N.-H. Tan Structure and Phylogeny of the Venom Group I Phospholipase A2 Gene Mol. Biol. Evol., July 1, 2000; 17(7): 1010 - 1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Costas and H. Naveira Evolutionary History of the Human Endogenous Retrovirus Family ERV9 Mol. Biol. Evol., February 1, 2000; 17(2): 320 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Saito, K. Haruta, M. Shimuta, H. Inoue, H. Sakurai, K. Yamada, N. Ishimaru, H. Higashiyama, T. Sumida, H. Ishida, et al. Fas Ligand-Mediated Exocrinopathy Resembling Sjogren's Syndrome in Mice Transgenic for IL-10 J. Immunol., March 1, 1999; 162(5): 2488 - 2494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Knössl, R. Löwer, and J. Löwer Expression of the Human Endogenous Retrovirus HTDV/HERV-K Is Enhanced by Cellular Transcription Factor YY1 J. Virol., February 1, 1999; 73(2): 1254 - 1261. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Schulte and A. Wellstein Structure and Phylogenetic Analysis of an Endogenous Retrovirus Inserted into the Human Growth Factor Gene Pleiotrophin J. Virol., July 1, 1998; 72(7): 6065 - 6072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Kowalski and D. L. Mager A Human Endogenous Retrovirus Suppresses Translation of an Associated Fusion Transcript, PLA2L J. Virol., July 1, 1998; 72(7): 6164 - 6168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Polidoros and J. G. Scandalios Circadian Expression of the Maize Catalase Cat3 Gene Is Highly Conserved Among Diverse Maize Genotypes With Structurally Different Promoters Genetics, May 1, 1998; 149(1): 405 - 415. [Abstract] [Full Text]
|
|
|
|
|
|
D. P. Wade, L. H. Puckey, B. L. Knight, F. Acquati, A. Mihalich, and R. Taramelli Characterization of Multiple Enhancer Regions Upstream of the Apolipoprotein(a) Gene J. Biol. Chem., November 28, 1997; 272(48): 30387 - 30399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Boyd, B. Foley, and I. Brodsky Evidence for Copurification of HERV-K-Related Transcripts and a Reverse Transcriptase Activity in Human Platelets From Patients With Essential Thrombocythemia Blood, November 15, 1997; 90(10): 4022 - 4030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Schulte, S. Lai, A. Kurtz, F. Czubayko, A. T. Riegel, and A. Wellstein Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus PNAS, December 10, 1996; 93(25): 14759 - 14764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pantel, K. Machinis, M.-L. Sobrier, P. Duquesnoy, M. Goossens, and S. Amselem Species-specific Alternative Splice Mimicry at the Growth Hormone Receptor Locus Revealed by the Lineage of Retroelements during Primate Evolution. A NOVEL MECHANISM ACCOUNTING FOR PROTEIN DIVERSITY BETWEEN AND WITHIN SPECIES J. Biol. Chem., June 16, 2000; 275(25): 18664 - 18669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Medstrand, J.-R. Landry, and D. L. Mager Long Terminal Repeats Are Used as Alternative Promoters for the Endothelin B Receptor and Apolipoprotein C-I Genes in Humans J. Biol. Chem., January 12, 2001; 276(3): 1896 - 1903. [Abstract] [Full Text] [PDF]
|
|
