QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Savant-Bhonsale, S Articles by Montell, D J Search for Related Content PubMed PubMed Citation Articles by Savant-Bhonsale, S Articles by Montell, D J Social Bookmarking                   What's this?

Research Papers

torso-like encodes the localized determinant of Drosophila terminal pattern formation.

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Abstract

Differentiation of the anterior and posterior poles of the Drosophila embryo requires seven maternally expressed genes including torso-like (tsl) and torso (tor). The tor gene encodes a receptor tyrosine kinase that is expressed throughout the embryo but is activated specifically at the poles. Genetic mosaic analysis has shown that tsl is required during oogenesis in follicle cells at each end of the oocyte. We cloned the tsl locus and showed that it was expressed specifically in follicle cells at the anterior and posterior ends of the oocyte. tsl encodes a novel protein with a putative amino-terminal signal sequence. Ectopic expression of tsl produced embryos with a phenotype similar to that resulting from constitutively active Tor alleles. These results suggest that localized TSL controls the localized activation of TOR.

CiteULike

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				M. Furriols, G. Ventura, and J. Casanova Two distinct but convergent groups of cells trigger Torso receptor tyrosine kinase activation by independently expressing torso-like PNAS, July 10, 2007; 104(28): 11660 - 11665. [Abstract] [Full Text] [PDF]

				G. Deshpande, G. Calhoun, and P. Schedl Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline Development, March 15, 2004; 131(6): 1247 - 1257. [Abstract] [Full Text] [PDF]

				S. Merabet, F. Catala, J. Pradel, and Y. Graba A Green Fluorescent Protein Reporter Genetic Screen That Identifies Modifiers of Hox Gene Function in the Drosophila Embryo Genetics, September 1, 2002; 162(1): 189 - 202. [Abstract] [Full Text] [PDF]

				G. Jimenez, A. Gonzalez-Reyes, and J. Casanova Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis Genes & Dev., April 15, 2002; 16(8): 913 - 918. [Abstract] [Full Text] [PDF]

				D. Stein and L. M. Stevens The Torso Ligand, Unmasked? Sci. Signal., September 4, 2001; 2001(98): pe2 - pe2. [Abstract] [Full Text] [PDF]

				D. Andrenacci, F. M. Cernilogar, C. Taddei, D. Rotoli, V. Cavaliere, F. Graziani, and G. Gargiulo Specific domains drive VM32E protein distribution and integration in Drosophila eggshell layers J. Cell Sci., January 8, 2001; 114(15): 2819 - 2829. [Abstract] [Full Text] [PDF]

				A Casali and J Casanova The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo Development, January 5, 2001; 128(9): 1709 - 1715. [Abstract] [PDF]

				V Schaeffer, D Killian, C Desplan, and E. Wimmer High bicoid levels render the terminal system dispensable for Drosophila head development Development, January 9, 2000; 127(18): 3993 - 3999. [Abstract] [PDF]

				H Araujo and E Bier sog and dpp exert opposing maternal functions to modify toll signaling and pattern the dorsoventral axis of the Drosophila embryo Development, January 8, 2000; 127(16): 3631 - 3644. [Abstract] [PDF]

				D. Han, D Stein, and L. Stevens Investigating the function of follicular subpopulations during Drosophila oogenesis through hormone-dependent enhancer-targeted cell ablation Development, January 2, 2000; 127(3): 573 - 583. [Abstract] [PDF]

				A. C. Spradling, D. Stern, A. Beaton, E. J. Rhem, T. Laverty, N. Mozden, S. Misra, and G. M. Rubin The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes Genetics, September 1, 1999; 153(1): 135 - 177. [Abstract] [Full Text]

				V. Schaeffer, F. Janody, C. Loss, C. Desplan, and E. A. Wimmer Bicoid functions without its TATA-binding protein-associated factor interaction domains PNAS, April 13, 1999; 96(8): 4461 - 4466. [Abstract] [Full Text] [PDF]

				J. Duffy, D. Harrison, and N Perrimon Identifying loci required for follicular patterning using directed mosaics Development, January 6, 1998; 125(12): 2263 - 2271. [Abstract] [PDF]

				M. Konsolaki and T. Schüpbach windbeutel, a gene required for dorsoventral patterning in Drosophila, encodes a protein that has homologies to vertebrate proteins of the endoplasmic reticulum Genes & Dev., January 1, 1998; 12(1): 120 - 131. [Abstract] [Full Text]

				S Greenwood and G Struhl Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos Development, January 12, 1997; 124(23): 4879 - 4886. [Abstract] [PDF]

				Z Paroush, S. Wainwright, and D Ish-Horowicz Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression Development, January 10, 1997; 124(19): 3827 - 3834. [Abstract] [PDF]

				L Gabay, R Seger, and B. Shilo MAP kinase in situ activation atlas during Drosophila embryogenesis Development, January 9, 1997; 124(18): 3535 - 3541. [Abstract] [PDF]

				R P Ray and T Schupbach Intercellular signaling and the polarization of body axes during Drosophila oogenesis. Genes & Dev., July 15, 1996; 10(14): 1711 - 1723. [PDF]

				E Sonnenberg-Riethmacher, B Walter, D Riethmacher, S Godecke, and C Birchmeier The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes & Dev., May 15, 1996; 10(10): 1184 - 1193. [Abstract] [PDF]

				S Emmons, H Phan, J Calley, W Chen, B James, and L Manseau Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Genes & Dev., October 15, 1995; 9(20): 2482 - 2494. [Abstract] [PDF]

				J Casanova, M Furriols, C A McCormick, and G Struhl Similarities between trunk and spatzle, putative extracellular ligands specifying body pattern in Drosophila. Genes & Dev., October 15, 1995; 9(20): 2539 - 2544. [Abstract] [PDF]

				A. Murphy, T Lee, C. Andrews, B. Shilo, and D. Montell The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration Development, January 8, 1995; 121(8): 2255 - 2263. [Abstract] [PDF]

				D Greenstein, S Hird, R H Plasterk, Y Andachi, Y Kohara, B Wang, M Finney, and G Ruvkun Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation. Genes & Dev., August 15, 1994; 8(16): 1935 - 1948. [Abstract] [PDF]

				J Rusch and M Levine Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression. Genes & Dev., June 1, 1994; 8(11): 1247 - 1257. [Abstract] [PDF]

				U Grossniklaus, K. Cadigan, and W. Gehring Three maternal coordinate systems cooperate in the patterning of the Drosophila head Development, January 11, 1994; 120(11): 3155 - 3171. [Abstract] [PDF]