.gif?ad=16839&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029-6574.
To test whether the mouse Hox-1.3 gene is a cognate of the Drosophila Sex combs reduced (Scr) gene, we inserted a hsp 70-Hox-1.3 fusion gene into the Drosophila genome. Transgenic flies displayed Scr-like homeotic transformations after ectopic expression of Hox-1.3 induced by heat shock. In larvae, the thoracic segments T2 and T3 are transformed toward T1. In adults, head structures are dramatically disrupted, including transformation of antenna towards leg. Transformations are not the result of ectopic activation of the endogenous Scr gene. Rather, Hox-1.3 appears to directly regulate Scr target genes, as demonstrated by the ectopic activation of fork head by Hox-1.3. The results suggest that mouse Hox-1.3 cannot only substitute functionally for Drosophila Scr in the determination of external structures but also can participate in the regulatory hierarchy of insect organogenesis.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. T. Hittinger, D. L. Stern, and S. B. Carroll Pleiotropic functions of a conserved insect-specific Hox peptide motif Development, December 1, 2005; 132(23): 5261 - 5270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Manfroid, X. Caubit, S. Kerridge, and L. Fasano Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene Development, March 1, 2004; 131(5): 1065 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Shaw, X. Zhang, A. F. Russo, B. A. Amendt, S. Henderson, and V. Williams Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands J. Histochem. Cytochem., March 1, 2003; 51(3): 385 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Brown, J. P. Fellers, T. D. Shippy, E. A. Richardson, M. Maxwell, J. J. Stuart, and R. E. Denell Sequence of the Tribolium castaneum Homeotic Complex: The Region Corresponding to the Drosophila melanogaster Antennapedia Complex Genetics, March 1, 2002; 160(3): 1067 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Grenier and S. B. Carroll Functional evolution of the Ultrabithorax protein PNAS, January 18, 2000; 97(2): 704 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ryoo, T Marty, F Casares, M Affolter, and R. Mann Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex Development, January 11, 1999; 126(22): 5137 - 5148. [Abstract] [PDF]
|
|
|
|
 |
|
 M. A. Viganò, G. Di Rocco, V. Zappavigna, and F. Mavilio Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context Mol. Cell. Biol., November 1, 1998; 18(11): 6201 - 6212. [Abstract] [Full Text]
|
|
|
|
|
|
A. Percival-Smith and D. J. Hayden Analysis in Drosophila melanogaster of the Interaction Between Sex Combs Reduced and Extradenticle Activity in the Determination of Tarsus and Arista Identity Genetics, September 1, 1998; 150(1): 189 - 198. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. M. Duncan, E. A. Burgess, and I. Duncan Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor Genes & Dev., May 1, 1998; 12(9): 1290 - 1303. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. A. KENNISON, M. VAZQUEZ, and B. J. BRIZUELA Regulation of the Sex Combs Reduced Gene in Drosophila Ann. N.Y. Acad. Sci., April 15, 1998; 842(1): 28 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nagao, S. Leuzinger, D. Acampora, A. Simeone, R. Finkelstein, H. Reichert, and K. Furukubo-Tokunaga Developmental rescue of Drosophila cephalic defects by the human Otx genes PNAS, March 31, 1998; 95(7): 3737 - 3742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-G. Belting, C. S. Shashikant, and F. H. Ruddle Modification of expression and cis-regulation of Hoxc8 in the evolution of diverged axial morphology PNAS, March 3, 1998; 95(5): 2355 - 2360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hanks, C. Loomis, E Harris, C. Tong, L Anson-Cartwright, A Auerbach, and A Joyner Drosophila engrailed can substitute for mouse Engrailed1 function in mid-hindbrain, but not limb development Development, January 11, 1998; 125(22): 4521 - 4530. [Abstract] [PDF]
|
|
|
|
|
|
G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice Development, January 8, 1998; 125(16): 3037 - 3048. [Abstract] [PDF]
|
|
|
|
|
|
T. E. Haerry and W. J. Gehring Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila PNAS, November 26, 1996; 93(24): 13884 - 13889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zhu and M. A. Kuziora Homeodomain Interaction with the beta Subunit of the General Transcription Factor TFIIE J. Biol. Chem., August 30, 1996; 271(35): 20993 - 20996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Lutz, H C Lu, G Eichele, D Miller, and T C Kaufman Rescue of Drosophila labial null mutant by the chicken ortholog Hoxb-1 demonstrates that the function of Hox genes is phylogenetically conserved. Genes & Dev., January 15, 1996; 10(2): 176 - 184. [Abstract] [PDF]
|
|
|
|
|
|
A Zhu and M. Kuziora Functional domains in the Deformed protein Development, January 5, 1996; 122(5): 1577 - 1587. [Abstract] [PDF]
|
|
|
|
 |
|
 G Halder, P Callaerts, and W. Gehring Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila Science, March 24, 1995; 267(5205): 1788 - 1792. [Abstract] [PDF]
|
|
|
|
|
|
P Rorth Specification of C/EBP function during Drosophila development by the bZIP basic region Science, December 16, 1994; 266(5192): 1878 - 1881. [Abstract] [PDF]
|
|
|
|
|
|
L. Mathies, S Kerridge, and M. Scott Role of the teashirt gene in Drosophila midgut morphogenesis: secreted proteins mediate the action of homeotic genes Development, January 10, 1994; 120(10): 2799 - 2809. [Abstract] [PDF]
|
|
|
|
|
|
L Jeannotte, M Lemieux, J Charron, F Poirier, and E J Robertson Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene. Genes & Dev., November 1, 1993; 7(11): 2085 - 2096. [Abstract] [PDF]
|
|
