.gif?ad=16248&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Rockefeller University, New York, New York 10021.
Abstract
Transcription factor NF-kappa B (p50/p65) is generally localized to the cytoplasm by its inhibitor I kappa B. Overproduced I kappa B, free from NF-kappa B, is rapidly degraded. Overexpression of p65 increases endogenous I kappa B protein in both carcinoma and lymphoid cells by two mechanisms: protein stabilization and increased transcription of I kappa B mRNA. In contrast, p65 delta, a naturally occurring splice variant, fails to markedly augment I kappa B protein levels. Both overexpressed p65 and coexpressed p50 are cytoplasmic, whereas p65 delta is partly nuclear, indicating that the I kappa B induced by p65 can maintain NF-kappa B in the cytoplasm. Thus, p65 and I kappa B are linked in an autoregulatory loop, ensuring that NF-kappa B is held in the cytoplasm until cells are specifically induced to translocate it to the nucleus.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Leleu, J. Eeckhoute, X. Jia, A. M. Roccaro, A.-S. Moreau, M. Farag, A. Sacco, H. T. Ngo, J. Runnels, M. R. Melhem, et al. Targeting NF-{kappa}B in Waldenstrom macroglobulinemia Blood, May 15, 2008; 111(10): 5068 - 5077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Makino, R. Uenishi, K. Okamoto, T. Isoe, O. Hosono, H. Tanaka, A. Kanopka, L. Poellinger, M. Haneda, and C. Morimoto Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1): A NEGATIVE FEEDBACK REGULATORY CIRCUIT IN HIF-1-MEDIATED SIGNALING IN HYPOXIC CELLS J. Biol. Chem., May 11, 2007; 282(19): 14073 - 14082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. d. Paz, S. Simeonidis, C. Leo, D. W. Rose, and T. Collins Regulation of NF-{kappa}B-dependent Gene Expression by the POU Domain Transcription Factor Oct-1 J. Biol. Chem., March 16, 2007; 282(11): 8424 - 8434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pummila, I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff, and M. L. Mikkola Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression Development, January 1, 2007; 134(1): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. E. Truhlar, J. W. Torpey, and E. A. Komives Regions of I{kappa}B{alpha} that are critical for its inhibition of NF-{kappa}B{middle dot}DNA interaction fold upon binding to NF-{kappa}B PNAS, December 12, 2006; 103(50): 18951 - 18956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Minami, M. Miura, W. C. Aird, and T. Kodama Thrombin-induced Autoinhibitory Factor, Down Syndrome Critical Region-1, Attenuates NFAT-dependent Vascular Cell Adhesion Molecule-1 Expression and Inflammation in the Endothelium J. Biol. Chem., July 21, 2006; 281(29): 20503 - 20520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Krishna, M. H. Jensen, and K. Sneppen Minimal model of spiky oscillations in NF-{kappa}B signaling PNAS, July 18, 2006; 103(29): 10840 - 10845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Kearns, S. Basak, S. L. Werner, C. S. Huang, and A. Hoffmann I{kappa}B{varepsilon} provides negative feedback to control NF-{kappa}B oscillations, signaling dynamics, and inflammatory gene expression J. Cell Biol., June 5, 2006; 173(5): 659 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Tong and P. A. Coulombe Keratin 17 modulates hair follicle cycling in a TNF{alpha}-dependent fashion. Genes & Dev., May 15, 2006; 20(10): 1353 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hu, Z. Han, A. D. Couvillon, R. J. Kaufman, and J. H. Exton Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1{alpha}-Mediated NF-{kappa}B Activation and Down-Regulation of TRAF2 Expression Mol. Cell. Biol., April 15, 2006; 26(8): 3071 - 3084. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tao, D. Yan, Q. Yang, R. Zeng, and Y. Wang Low K+ Promotes NF-{kappa}B/DNA Binding in Neuronal Apoptosis Induced by K+ Loss Mol. Cell. Biol., February 1, 2006; 26(3): 1038 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Covert, T. H. Leung, J. E. Gaston, and D. Baltimore Achieving Stability of Lipopolysaccharide-Induced NF-{kappa}B Activation Science, September 16, 2005; 309(5742): 1854 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. B. Hammar, J.-C. Irminger, K. Rickenbach, G. Parnaud, P. Ribaux, D. Bosco, D. G. Rouiller, and P. A. Halban Activation of NF-{kappa}B by Extracellular Matrix Is Involved in Spreading and Glucose-stimulated Insulin Secretion of Pancreatic Beta Cells J. Biol. Chem., August 26, 2005; 280(34): 30630 - 30637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Motoyama, S. Yamazaki, A. Eto-Kimura, K. Takeshige, and T. Muta Positive and Negative Regulation of Nuclear Factor-{kappa}B-mediated Transcription by I{kappa}B-{zeta}, an Inducible Nuclear Protein J. Biol. Chem., March 4, 2005; 280(9): 7444 - 7451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Deng, P. D. Lu, Y. Zhang, D. Scheuner, R. J. Kaufman, N. Sonenberg, H. P. Harding, and D. Ron Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2 Mol. Cell. Biol., December 1, 2004; 24(23): 10161 - 10168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Minami, K. Horiuchi, M. Miura, Md. R. Abid, W. Takabe, N. Noguchi, T. Kohro, X. Ge, H. Aburatani, T. Hamakubo, et al. Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis J. Biol. Chem., November 26, 2004; 279(48): 50537 - 50554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saccani, I. Marazzi, A. A. Beg, and G. Natoli Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor {kappa}B Response J. Exp. Med., November 8, 2004; (2004) jem.20040196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wu, M. Tan, Y. Hu, J.-L. Wang, D. Scheuner, and R. J. Kaufman Ultraviolet Light Activates NF{kappa}B through Translational Inhibition of I{kappa}B{alpha} Synthesis J. Biol. Chem., August 13, 2004; 279(33): 34898 - 34902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Sorokina, J. J. Merlo Jr., and A. Y. Tsygankov Molecular Mechanisms of the Effect of Herpesvirus saimiri Protein StpC on the Signaling Pathway Leading to NF-{kappa}B Activation J. Biol. Chem., April 2, 2004; 279(14): 13469 - 13477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, C. Domon-Dell, J. Kang, D. H. Chung, J.-N. Freund, and B. M. Evers Down-regulation of the Tumor Suppressor PTEN by the Tumor Necrosis Factor-{alpha}/Nuclear Factor-{kappa}B (NF-{kappa}B)-inducing Kinase/NF-{kappa}B Pathway Is Linked to a Default I{kappa}B-{alpha} Autoregulatory Loop J. Biol. Chem., February 6, 2004; 279(6): 4285 - 4291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Prendes, Y. Zheng, and A. A. Beg Regulation of Developing B Cell Survival by RelA-Containing NF-{kappa}B Complexes J. Immunol., October 15, 2003; 171(8): 3963 - 3969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Galindo, J. Sha, D. A. Ribardo, A. A. Fadl, L. Pillai, and A. K. Chopra Identification of Aeromonas hydrophila Cytotoxic Enterotoxin-induced Genes in Macrophages Using Microarrays J. Biol. Chem., October 10, 2003; 278(41): 40198 - 40212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wu and S. Ghosh Differential Phosphorylation of the Signal-responsive Domain of I{kappa}B{alpha} and I{kappa}B{beta} by I{kappa}B Kinases J. Biol. Chem., August 22, 2003; 278(34): 31980 - 31987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-J. Liu, S.-C. Hou, and C.-K. J. Shen Erythroid Gene Suppression by NF-{kappa}B J. Biol. Chem., May 23, 2003; 278(21): 19534 - 19540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Ladner, M. A. Caligiuri, and D. C. Guttridge Tumor Necrosis Factor-regulated Biphasic Activation of NF-kappa B Is Required for Cytokine-induced Loss of Skeletal Muscle Gene Products J. Biol. Chem., January 17, 2003; 278(4): 2294 - 2303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pahl and K. Brune Stabilization of Gene Expression Profiles in Blood after Phlebotomy Clin. Chem., December 1, 2002; 48(12): 2251 - 2253. [Full Text] [PDF]
|
|
|
|
|
|
A. Hoffmann, A. Levchenko, M. L. Scott, and D. Baltimore The Ikappa B-NF-kappa B Signaling Module: Temporal Control and Selective Gene Activation Science, November 8, 2002; 298(5596): 1241 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y. Chang, J.-T. Chi, S. Dudoit, C. Bondre, M. van de Rijn, D. Botstein, and P. O. Brown Diversity, topographic differentiation, and positional memory in human fibroblasts PNAS, October 1, 2002; 99(20): 12877 - 12882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Davis, K. D. Brown, U. Siebenlist, and L. M. Staudt Constitutive Nuclear Factor {kappa}B Activity Is Required for Survival of Activated B Cell-like Diffuse Large B Cell Lymphoma Cells J. Exp. Med., December 17, 2001; 194(12): 1861 - 1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Baetu, H. Kwon, S. Sharma, N. Grandvaux, and J. Hiscott Disruption of NF-{kappa}B Signaling Reveals a Novel Role for NF-{kappa}B in the Regulation of TNF-Related Apoptosis-Inducing Ligand Expression J. Immunol., September 15, 2001; 167(6): 3164 - 3173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Blondeau, C. Widmann, M. Lazdunski, and C. Heurteaux Activation of the Nuclear Factor-{kappa}B Is a Key Event in Brain Tolerance J. Neurosci., July 1, 2001; 21(13): 4668 - 4677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bureau, S. Delhalle, G. Bonizzi, L. Fievez, S. Dogne, N. Kirschvink, A. Vanderplasschen, M.-P. Merville, V. Bours, and P. Lekeux Mechanisms of Persistent NF-{kappa}B Activity in the Bronchi of an Animal Model of Asthma J. Immunol., November 15, 2000; 165(10): 5822 - 5830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rudolph, W.-C. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A. J. Elia, and T. W. Mak Severe liver degeneration and lack of NF-kappa B activation in NEMO/IKKgamma -deficient mice Genes & Dev., April 1, 2000; 14(7): 854 - 862. [Abstract] [Full Text]
|
|
|
|
|
|
W. F. Tam, L. H. Lee, L. Davis, and R. Sen Cytoplasmic Sequestration of Rel Proteins by Ikappa Balpha Requires CRM1-Dependent Nuclear Export Mol. Cell. Biol., March 15, 2000; 20(6): 2269 - 2284. [Abstract] [Full Text]
|
|
|
|
|
|
L. M. Staudt The Molecular and Cellular Origins of Hodgkin's Disease J. Exp. Med., January 17, 2000; 191(2): 207 - 212. [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kirillova, M. Chaisson, and N. Fausto Tumor Necrosis Factor Induces DNA Replication in Hepatic Cells through Nuclear Factor {{kappa}}B Activation Cell Growth Differ., December 1, 1999; 10(12): 819 - 828. [Abstract] [Full Text]
|
|
|
|
|
|
S. Memet, D. Laouini, J.-C. Epinat, S. T. Whiteside, B. Goudeau, D. Philpott, S. Kayal, P. J. Sansonetti, P. Berche, J. Kanellopoulos, et al. I{kappa}B{epsilon}-Deficient Mice: Reduction of One T Cell Precursor Subspecies and Enhanced Ig Isotype Switching and Cytokine Synthesis J. Immunol., December 1, 1999; 163(11): 5994 - 6005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia, S. Chen, Y. Wang, N. Mackman, G. Ku, D. Lo, and L. Feng RelB Modulation of Ikappa Balpha Stability as a Mechanism of Transcription Suppression of Interleukin-1alpha (IL-1alpha ), IL-1beta , and Tumor Necrosis Factor Alpha in Fibroblasts Mol. Cell. Biol., November 1, 1999; 19(11): 7688 - 7696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Harhaj and S.-C. Sun Regulation of RelA Subcellular Localization by a Putative Nuclear Export Signal and p50 Mol. Cell. Biol., October 1, 1999; 19(10): 7088 - 7095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shirane, S. Hatakeyama, K. Hattori, K. Nakayama, and K.-i. Nakayama Common Pathway for the Ubiquitination of Ikappa Balpha , Ikappa Bbeta , and Ikappa Bepsilon Mediated by the F-Box Protein FWD1 J. Biol. Chem., October 1, 1999; 274(40): 28169 - 28174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Algarte, H. Kwon, P. Genin, and J. Hiscott Identification by In Vivo Genomic Footprinting of a Transcriptional Switch Containing NF-kappa B and Sp1 That Regulates the Ikappa Balpha Promoter Mol. Cell. Biol., September 1, 1999; 19(9): 6140 - 6153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Doerre and R. B. Corley Constitutive Nuclear Translocation of NF-{kappa}B in B Cells in the Absence of I{kappa}B Degradation J. Immunol., July 1, 1999; 163(1): 269 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Li, D. V. Antwerp, F. Mercurio, K. Lee, and I. M. Verma Severe Liver Degeneration in Mice Lacking the IB Kinase 2 Gene Science, April 9, 1999; 284(5412): 321 - 325. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Sheehy and M. S. Schlissel Overexpression of RelA Causes G1 Arrest and Apoptosis in a Pro-B Cell Line J. Biol. Chem., March 26, 1999; 274(13): 8708 - 8716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Spencer, J. Jiang, and Z. J. Chen Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP Genes & Dev., February 1, 1999; 13(3): 284 - 294. [Abstract] [Full Text]
|
|
|
|
|
|
T. R. Torgerson, A. D. Colosia, J. P. Donahue, Y.-Z. Lin, and J. Hawiger Regulation of NF-{kappa}B, AP-1, NFAT, and STAT1 Nuclear Import in T Lymphocytes by Noninvasive Delivery of Peptide Carrying the Nuclear Localization Sequence of NF-{kappa}B p50 J. Immunol., December 1, 1998; 161(11): 6084 - 6092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Harhaj and S.-C. Sun Ikappa B Kinases Serve as a Target of CD28 Signaling J. Biol. Chem., September 25, 1998; 273(39): 25185 - 25190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Cuervo, W. Hu, B. Lim, and J. F. Dice Ikappa B Is a Substrate for a Selective Pathway of Lysosomal Proteolysis Mol. Biol. Cell, August 1, 1998; 9(8): 1995 - 2010. [Abstract] [Full Text]
|
|
|
|
|
|
J. Ochoa-Garay, J. Kaye, and J. E. Coligan Nuclear Factor {kappa}B Is Required for Peptide Antigen-Induced Differentiation of a CD4+CD8+ Thymocyte Line J. Immunol., April 15, 1998; 160(8): 3835 - 3843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Reuther, G. W. Reuther, D. Cortez, A. M. Pendergast, and A. S. Baldwin Jr. A requirement for NF-kappa B activation in Bcr-Abl-mediated transformation Genes & Dev., April 1, 1998; 12(7): 968 - 981. [Abstract] [Full Text]
|
|
|
|
|
|
I. Luque and C. Gélinas Distinct Domains of Ikappa Balpha Regulate c-Rel in the Cytoplasm and in the Nucleus Mol. Cell. Biol., March 1, 1998; 18(3): 1213 - 1224. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Attar, H. Macdonald-Bravo, C. Raventos-Suarez, S. K. Durham, and R. Bravo Expression of Constitutively Active Ikappa Bbeta in T Cells of Transgenic Mice: Persistent NF-kappa B Activity Is Required for T-Cell Immune Responses Mol. Cell. Biol., January 1, 1998; 18(1): 477 - 487. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Woronicz, X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel I  B Kinase- : NF-B Activation and Complex Formation with IB Kinase- and NIKScience, October 31, 1997; 278(5339): 866 - 870. [Abstract] [Full Text]
|
|
|
|
|
|
I. M. Verma and J. Stevenson Ikappa B kinase: Beginning, not the end PNAS, October 28, 1997; 94(22): 11758 - 11760. [Full Text] [PDF]
|
|
|
|
|
|
E. W. Harhaj and S.-C. Sun The Serine/Threonine Phosphatase Inhibitor Calyculin A Induces Rapid Degradation of Ikappa Bbeta . REQUIREMENT OF BOTH THE N- AND C-TERMINAL SEQUENCES J. Biol. Chem., February 28, 1997; 272(9): 5409 - 5412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Singh, B. G. Darnay, and B. B. Aggarwal Site-specific Tyrosine Phosphorylation of Ikappa Balpha Negatively Regulates Its Inducible Phosphorylation and Degradation J. Biol. Chem., December 6, 1996; 271(49): 31049 - 31054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Beg and D. Baltimore An Essential Role for NF-kappa B in Preventing TNF-alpha -Induced Cell Death Science, November 1, 1996; 274(5288): 782 - 784. [Abstract] [Full Text]
|
|
|
|
|
|
I M Verma, J K Stevenson, E M Schwarz, D Van Antwerp, and S Miyamoto Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes & Dev., November 15, 1995; 9(22): 2723 - 2735. [PDF]
|
|
|
|
|
|
A A Beg, W C Sha, R T Bronson, and D Baltimore Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes & Dev., November 15, 1995; 9(22): 2736 - 2746. [Abstract] [PDF]
|
|
|
|
|
|
|
