.gif?ad=16839&adview=true)
![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Research Papers
Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Abstract
The microphthalmia (mi) gene appears essential for pigment cell development and/or survival, based on its mutation in mi mice. It has also been linked to the human disorder Waardenburg Syndrome. The mi gene was recently cloned and predicts a basic/helix-loop-helix/leucine zipper (b-HLH-ZIP) factor with tissue-restricted expression. Here, we show that Mi protein binds DNA as a homo- or heterodimer with TFEB, TFE3, or TFEC, together constituting a new MiT family. Mi can also activate transcription through recognition of the M box, a highly conserved pigmentation gene promoter element, and may thereby determine tissue-specific expression of pigmentation enzymes. Six mi mutations shown recently to cluster in the b-HLH-ZIP region produce surprising and instructive effects on DNA recognition and oligomerization. An alternatively spliced exon located outside of the b-HLH-ZIP region is shown to significantly modulate DNA recognition by the basic domain. These findings suggest that Mi's critical roles in melanocyte survival and pigmentation are mediated by MiT family interactions and transcriptional activities.
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. N. Dynek, S. M. Chan, J. Liu, J. Zha, W. J. Fairbrother, and D. Vucic Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas Cancer Res., May 1, 2008; 68(9): 3124 - 3132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sato-Jin, E. K. Nishimura, E. Akasaka, W. Huber, H. Nakano, A. Miller, J. Du, M. Wu, K. Hanada, D. Sawamura, et al. Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders FASEB J, April 1, 2008; 22(4): 1155 - 1168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bismuth, S. Skuntz, J. H. Hallsson, E. Pak, A. S. Dutra, E. Steingrimsson, and H. Arnheiter An Unstable Targeted Allele of the Mouse Mitf Gene With a High Somatic and Germline Reversion Rate Genetics, January 1, 2008; 178(1): 259 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tshori, A. Sonnenblick, N. Yannay-Cohen, G. Kay, H. Nechushtan, and E. Razin Microphthalmia Transcription Factor Isoforms in Mast Cells and the Heart Mol. Cell. Biol., June 1, 2007; 27(11): 3911 - 3919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Sharma, A. Bronisz, R. Hu, K. Patel, K. C. Mansky, S. Sif, and M. C. Ostrowski MITF and PU.1 Recruit p38 MAPK and NFATc1 to Target Genes during Osteoclast Differentiation J. Biol. Chem., May 25, 2007; 282(21): 15921 - 15929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takeda, T. Adachi, F. Han, S. Yokoyama, H. Yamamoto, W. Hida, and S. Shibahara Augmented Chemosensitivity in Black-Eyed White Mitf mi-bw Mice, Lacking Melanocytes J. Biochem., March 1, 2007; 141(3): 327 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Esumi, S. Kachi, P. A. Campochiaro, and D. J. Zack VMD2 Promoter Requires Two Proximal E-box Sites for Its Activity in Vivo and Is Regulated by the MITF-TFE Family J. Biol. Chem., January 19, 2007; 282(3): 1838 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Meadows, S. M. Sharma, G. J. Faulkner, M. C. Ostrowski, D. A. Hume, and A. I. Cassady The Expression of Clcn7 and Ostm1 in Osteoclasts Is Coregulated by Microphthalmia Transcription Factor J. Biol. Chem., January 19, 2007; 282(3): 1891 - 1904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schepsky, K. Bruser, G. J. Gunnarsson, J. Goodall, J. H. Hallsson, C. R. Goding, E. Steingrimsson, and A. Hecht The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression Mol. Cell. Biol., December 1, 2006; 26(23): 8914 - 8927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chin, L. A. Garraway, and D. E. Fisher Malignant melanoma: genetics and therapeutics in the genomic era. Genes & Dev., August 15, 2006; 20(16): 2149 - 2182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. de la Serna, Y. Ohkawa, C. Higashi, C. Dutta, J. Osias, N. Kommajosyula, T. Tachibana, and A. N. Imbalzano The Microphthalmia-associated Transcription Factor Requires SWI/SNF Enzymes to Activate Melanocyte-specific Genes J. Biol. Chem., July 21, 2006; 281(29): 20233 - 20241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Koyanagi, S. J. O'Day, R. Gonzalez, K. Lewis, W. A. Robinson, T. T. Amatruda, C. Kuo, H.-J. Wang, R. Milford, D. L. Morton, et al. Microphthalmia Transcription Factor as a Molecular Marker for Circulating Tumor Cell Detection in Blood of Melanoma Patients Clin. Cancer Res., February 15, 2006; 12(4): 1137 - 1143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Molina, S. Grewal, and L. Bardwell Characterization of an ERK-binding Domain in Microphthalmia-associated Transcription Factor and Differential Inhibition of ERK2-mediated Substrate Phosphorylation J. Biol. Chem., December 23, 2005; 280(51): 42051 - 42060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Roundy, G. Spangrude, J. J. Weis, and J. H. Weis Partial rescue of B cells in microphthalmic osteopetrotic marrow by loss of response to type I IFNs Int. Immunol., November 1, 2005; 17(11): 1495 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Miller, C. Levy, I. J. Davis, E. Razin, and D. E. Fisher Sumoylation of MITF and Its Related Family Members TFE3 and TFEB J. Biol. Chem., January 7, 2005; 280(1): 146 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morii and K. Oboki MITF Is Necessary for Generation of Prostaglandin D2 in Mouse Mast Cells J. Biol. Chem., November 19, 2004; 279(47): 48923 - 48929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Morii, A. Ito, T. Jippo, Y.-i. Koma, K. Oboki, T. Wakayama, S. Iseki, M. L. Lamoreux, and Y. Kitamura Number of Mast Cells in the Peritoneal Cavity of Mice: Influence of Microphthalmia Transcription Factor through Transcription of Newly Found Mast Cell Adhesion Molecule, Spermatogenic Immunoglobulin Superfamily Am. J. Pathol., August 1, 2004; 165(2): 491 - 499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Hallsson, B. S. Haflidadottir, C. Stivers, W. Odenwald, H. Arnheiter, F. Pignoni, and E. Steingrimsson The Basic Helix-Loop-Helix Leucine Zipper Transcription Factor Mitf Is Conserved in Drosophila and Functions in Eye Development Genetics, May 1, 2004; 167(1): 233 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Esumi, Y. Oshima, Y. Li, P. A. Campochiaro, and D. J. Zack Analysis of the VMD2 Promoter and Implication of E-box Binding Factors in Its Regulation J. Biol. Chem., April 30, 2004; 279(18): 19064 - 19073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Kuiper, M. Schepens, J. Thijssen, E. F. P. M. Schoenmakers, and A. G. van Kessel Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains Nucleic Acids Res., April 26, 2004; 32(8): 2315 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamaguchi, S. Itami, H. Watabe, K.-i. Yasumoto, Z. A. Abdel-Malek, T. Kubo, F. Rouzaud, A. Tanemura, K. Yoshikawa, and V. J. Hearing Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation J. Cell Biol., April 26, 2004; 165(2): 275 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Miller, J. Du, S. Rowan, C. L. Hershey, H. R. Widlund, and D. E. Fisher Transcriptional Regulation of the Melanoma Prognostic Marker Melastatin (TRPM1) by MITF in Melanocytes and Melanoma Cancer Res., January 15, 2004; 64(2): 509 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Levy, A. Sonnenblick, and E. Razin Role Played by Microphthalmia Transcription Factor Phosphorylation and Its Zip Domain in Its Transcriptional Inhibition by PIAS3 Mol. Cell. Biol., December 15, 2003; 23(24): 9073 - 9080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Huber, E. R. Price, H. R. Widlund, J. Du, I. J. Davis, M. Wegner, and D. E. Fisher A Tissue-restricted cAMP Transcriptional Response: SOX10 MODULATES {alpha}-MELANOCYTE-STIMULATING HORMONE-TRIGGERED EXPRESSION OF MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR IN MELANOCYTES J. Biol. Chem., November 14, 2003; 278(46): 45224 - 45230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Maderspacher and C. Nusslein-Volhard Formation of the adult pigment pattern in zebrafish requires leopard and obelix dependent cell interactions Development, August 1, 2003; 130(15): 3447 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Kuiper, M. Schepens, J. Thijssen, M. van Asseldonk, E. van den Berg, J. Bridge, E. Schuuring, E. F.P.M. Schoenmakers, and A. G. van Kessel Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution Hum. Mol. Genet., July 15, 2003; 12(14): 1661 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Du, A. J. Miller, H. R. Widlund, M. A. Horstmann, S. Ramaswamy, and D. E. Fisher MLANA/MART1 and SILV/PMEL17/GP100 Are Transcriptionally Regulated by MITF in Melanocytes and Melanoma Am. J. Pathol., July 1, 2003; 163(1): 333 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. So, J. Rho, D. Jeong, R. Park, D. E. Fisher, M. C. Ostrowski, Y. Choi, and N. Kim Microphthalmia Transcription Factor and PU.1 Synergistically Induce the Leukocyte Receptor Osteoclast-associated Receptor Gene Expression J. Biol. Chem., June 20, 2003; 278(26): 24209 - 24216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Jippo, E. Morii, A. Ito, and Y. Kitamura Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial Infections: Demonstration Using Partially Mast Cell-deficient tg/tg Mice J. Exp. Med., June 2, 2003; 197(11): 1417 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Davis, B.-L. Hsi, J. D. Arroyo, S. O. Vargas, Y. A. Yeh, G. Motyckova, P. Valencia, A. R. Perez-Atayde, P. Argani, M. Ladanyi, et al. Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation PNAS, May 13, 2003; 100(10): 6051 - 6056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ito, T. Jippo, T. Wakayama, E. Morii, Y.-i. Koma, H. Onda, H. Nojima, S. Iseki, and Y. Kitamura SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF Blood, April 1, 2003; 101(7): 2601 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morii, K. Oboki, T. Jippo, and Y. Kitamura Additive effect of mouse genetic background and mutation of MITF gene on decrease of skin mast cells Blood, February 15, 2003; 101(4): 1344 - 1350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Steingrimsson, H. Arnheiter, J. H. Hallsson, M. L. Lamoreux, N. G. Copeland, and N. A. Jenkins Interallelic Complementation at the Mouse Mitf Locus Genetics, January 1, 2003; 163(1): 267 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Widlund, M. A. Horstmann, E. R. Price, J. Cui, S. L. Lessnick, M. Wu, X. He, and D. E. Fisher {beta}-Catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor J. Cell Biol., September 16, 2002; 158(6): 1079 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Takemoto, Y.-J. Yoon, and D. E. Fisher The Identification and Functional Characterization of a Novel Mast Cell Isoform of the Microphthalmia-associated Transcription Factor J. Biol. Chem., August 9, 2002; 277(33): 30244 - 30252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Saito, K.-i. Yasumoto, K. Takeda, K. Takahashi, A. Fukuzaki, S. Orikasa, and S. Shibahara Melanocyte-specific Microphthalmia-associated Transcription Factor Isoform Activates Its Own Gene Promoter through Physical Interaction with Lymphoid-enhancing Factor 1 J. Biol. Chem., August 2, 2002; 277(32): 28787 - 28794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Prado, G. Vicent, C. Cardalda, and M. Beato Differential Role of the Proline-rich Domain of Nuclear Factor 1-C Splice Variants in DNA Binding and Transactivation J. Biol. Chem., May 3, 2002; 277(19): 16383 - 16390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Steingrimsson, L. Tessarollo, B. Pathak, L. Hou, H. Arnheiter, N. G. Copeland, and N. A. Jenkins Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development PNAS, April 2, 2002; 99(7): 4477 - 4482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Mansky, U. Sankar, J. Han, and M. C. Ostrowski Microphthalmia Transcription Factor Is a Target of the p38 MAPK Pathway in Response to Receptor Activator of NF-kappa B Ligand Signaling J. Biol. Chem., March 22, 2002; 277(13): 11077 - 11083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawata, H. Suzuki, Y. Higaki, O. Denisenko, D. Schullery, C. Abrass, and K. Bomsztyk bcn-1 Element-dependent Activation of the Laminin gamma 1 Chain Gene by the Cooperative Action of Transcription Factor E3 (TFE3) and Smad Proteins J. Biol. Chem., March 22, 2002; 277(13): 11375 - 11384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Jimenez-Cervantes, M. Martinez-Esparza, C. Perez, N. Daum, F. Solano, and J. C. Garcia-Borron Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor J. Cell Sci., March 8, 2002; 114(12): 2335 - 2344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morii, K. Oboki, T. R. Kataoka, K. Igarashi, and Y. Kitamura Interaction and Cooperation of mi Transcription Factor (MITF) and Myc-associated Zinc-finger Protein-related Factor (MAZR) for Transcription of Mouse Mast Cell Protease 6 Gene J. Biol. Chem., March 1, 2002; 277(10): 8566 - 8571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Mansky, K. Marfatia, G. H. Purdom, A. Luchin, D. A. Hume, and M. C. Ostrowski The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts J. Leukoc. Biol., February 1, 2002; 71(2): 295 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Mansky, S. Sulzbacher, G. Purdom, L. Nelsen, D. A. Hume, M. Rehli, and M. C. Ostrowski The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter J. Leukoc. Biol., February 1, 2002; 71(2): 304 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Du and D. E. Fisher Identification of Aim-1 as the underwhite Mouse Mutant and Its Transcriptional Regulation by MITF J. Biol. Chem., January 4, 2002; 277(1): 402 - 406. [Abstract] [Full Text]
|
|
|
|
|
|
E. Morii, H. Ogihara, K. Oboki, T. R. Kataoka, K. Maeyama, D. E. Fisher, M. L. Lamoreux, and Y. Kitamura Effect of a large deletion of the basic domain of mi transcription factor on differentiation of mast cells Blood, October 15, 2001; 98(8): 2577 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morii, H. Ogihara, K. Oboki, C. Sawa, T. Sakuma, S. Nomura, J. D. Esko, H. Handa, and Y. Kitamura Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells Blood, May 15, 2001; 97(10): 3032 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Motyckova, K. N. Weilbaecher, M. Horstmann, D. J. Rieman, D. Z. Fisher, and D. E. Fisher Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family PNAS, April 25, 2001; (2001) 91479298. [Abstract] [Full Text]
|
|
|
|
|
|
E. Morii, H. Ogihara, D.-K. Kim, A. Ito, K. Oboki, Y.-M. Lee, T. Jippo, S. Nomura, K. Maeyama, M. L. Lamoreux, et al. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mice/mice mutant mice of which MITF lacks the zipper domain Blood, April 1, 2001; 97(7): 2038 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ito, T. R. Kataoka, D.-K. Kim, Y.-i. Koma, Y.-M. Lee, and Y. Kitamura Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice Blood, April 1, 2001; 97(7): 2075 - 2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ogihara, E. Morii, D.-K. Kim, K. Oboki, and Y. Kitamura Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene Blood, February 1, 2001; 97(3): 645 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ge, T. Jippo, Y.-M. Lee, S. Adachi, and Y. Kitamura Independent Influence of Strain Difference and mi Transcription Factor on the Expression of Mouse Mast Cell Chymases Am. J. Pathol., January 1, 2001; 158(1): 281 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Goding Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage Genes & Dev., July 15, 2000; 14(14): 1712 - 1728. [Full Text]
|
|
|
|
|
|
J. H. Hallsson, J. Favor, C. Hodgkinson, T. Glaser, M. L. Lamoreux, R. Magnúsdóttir, G. J. Gunnarsson, H. O. Sweet, N. G. Copeland, N. A. Jenkins, et al. Genomic, Transcriptional and Mutational Analysis of the Mouse microphthalmia Locus Genetics, May 1, 2000; 155(1): 291 - 300. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. Verastegui, C. Bertolotto, K. Bille, P. Abbe, J. P. Ortonne, and R. Ballotti TFE3, a Transcription Factor Homologous to Microphthalmia, Is a Potential Transcriptional Activator of Tyrosinase and TyrpI Genes Mol. Endocrinol., March 1, 2000; 14(3): 449 - 456. [Abstract] [Full Text]
|
|
|
|
|
|
M. Wu, T. J. Hemesath, C. M. Takemoto, M. A. Horstmann, A. G. Wells, E. R. Price, D. Z. Fisher, and D. E. Fisher c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi Genes & Dev., February 1, 2000; 14(3): 301 - 312. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Adachi, E. Morii, D.-k. Kim, H. Ogihara, T. Jippo, A. Ito, Y.-M. Lee, and Y |
