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Vol. 14, No. 21, pp. 2677-2688, November 1, 2000
1 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; 2 Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, CMU, 1211 Geneva 4, Switzerland
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Introduction |
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In the life of a cell, the plasma membrane fulfills a range of
functions that go far beyond the shaping and maintenance of architectural features and the absorption of nutrients. The plasma membrane is a highly sophisticated structure whose
phospholipidic backbone is loaded with proteins responsible for
channeling the stream of information that continuously flows between a
cell and its environment. Although the nucleus can intuitively be
viewed as the cell's center of command, the translation of its genetic content is constantly modulated by signals triggered and often integrated at the level of the plasma membrane. Reciprocally, the cell
exposes
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