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Vol. 16, No. 11, pp. 1307-1313, June 1, 2002

PERSPECTIVE
Transmission of proteotoxicity across cellular compartments

Takunari Yoneda, Fumihiko Urano, and David Ron¹

Skirball Institute of Biomolecular Medicine, Departments of Medicine and Cell Biology, New York University School of Medicine, New York, New York 10016, USA

The first 100 words of the full text of this article appear below.

	Introduction

An important subgroup of human neurodegenerative diseases is associated with abnormal expansions of glutamine repeats found in several otherwise unrelated proteins (Zoghbi and Orr 2000). Interest in these polyglutamine diseases is fueled both by their clinical significance and by the belief that lessons gleaned from these relatively rare conditions will apply to other more prevalent human neurodegenerative disorders and perhaps more generally to other diseases of aging. The basis for this belief is the observation that polyglutamine diseases and common neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, share as a common feature the accumulation of abnormal protein . . . [Full Text of this Article]

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