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Vol. 16, No. 17, pp. 2179-2206, September 1, 2002
1 Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA; 2 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8024, USA
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Introduction |
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The ability of cells to make exact replicas of themselves is central
to the life and development of complex organisms. Initial insights into the question of how cells divide came
during the latter half of the 19th century when Walther Flemming
visualized structures he called threads (which we now call chromosomes)
and described how these threads change during cell multiplication, a
process he called mitosis. Now, more than a century later, we have a
molecular understanding of many of the cellular processes that Flemming
observed. Indeed, major cytological events occurring during mitosis are
known to constitute cell cycle transitions and
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|
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|
|
|
|
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