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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA

The first 100 words of the full text of this article appear below.

The regulation of cell survival has a well-documented role in the maintenance of homeostasis, the damage response, and is misregulated in various disease states. Cancer, in particular, is one disease in which the failure to maintain an intact apoptotic response is associated with disease progression and treatment failure (Cory and Adams 2002). Apoptosis is regulated, in part, through dependence upon growth factors and cytokines. For example, the survival of lymphoid cells is closely controlled by specific cytokines, which provide an intricate selection process to determine the cells that should be maintained and those that should not. Whereas this cytokine . . . [Full Text of this Article]

	Pim-2 is regulated by IL-3

 

	Pim kinases and cancer

 

	Myc, apoptosis, and lymphomagenesis

 

	How does Pim-2 promote survival?

 

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