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GENES & DEVELOPMENT 17:2351-2355, 2003
©2003 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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Degradation of targeted mRNAs in Escherichia coli: regulation by a small antisense RNA

Agamemnon J. Carpousis1

Laboratoire de Microbiologie et Génétique Moléculaire (CNRS, UMR 5100) and Paul Sabatier Université, 31062 Toulouse, France

The first 100 words of the full text of this article appear below.

In this issue of Genes & Development, Massé et al. (2003aGo) show that a small antisense RNA (saRNA) triggers mRNA degradation via a pathway in which the saRNA is also consumed. The stoichiometric binding of the saRNA to its mRNA target thus appears to activate the degradation of both RNAs (coupled degradation).

The physical interaction of complementary polynucleotides is arguably the fundamental chemical principle underlying molecular genetics. It is the most important feature of the structure of double-stranded DNA, and it is at the heart of the mechanism by which tRNA decodes mRNA to synthesize protein. The article . . . [Full Text of this Article]


   Classical antisense
 

   Renaissance antisense
 

   Enlightened antisense
 

   Degradation of targeted mRNAs
 

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