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REVIEW
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
| The first 100 words of the full text of this article appear below. |
In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972
). This genetic program is vital for normal development, for maintenance of tissue homeostasis, and for an effective immune system. Not surprisingly therefore, its disturbance is implicated in numerous pathological conditions, ranging from degenerative disorders to autoimmunity and cancer (Cory and Adams 2002; Cory et al. 2003).
The cell's death throes are choreographed by a set of previously dormant proteases, the caspases, which cleave several hundred cellular substrates (Thornberry and Lazebnik 1998).
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The demolition machinery |
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The Bcl-2 family of apoptotic regulators |
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The mitochondrial `poison cabinet' |
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Amplification role of the apoptosome |
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Potential role of the ER in apoptosis |
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Potential apoptotic roles of initiator caspases other than caspase-9 |
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Caspase-2
Caspase-1 and caspase-11
Caspase-8
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Interplay of Bcl-2 family members in commitment to apoptosis |
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How might the Bcl-2 family control the activation of caspases? |
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Conclusions and conundrums |
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