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PERSPECTIVE

Ecsit-ement on the crossroads of Toll and BMP signal transduction

Ludwig Institute for Cancer Research, SE-751 24 Uppsala, Sweden

The first 100 words of the full text of this article appear below.

Elucidation of signaling networks and their specialized functions in different cell types represents a challenging scientific question. Establishment of signaling crosstalk between different pathways relies on biochemical evidence coupled to genetic analysis of key components of the pathways at stake, and definition of the epistatic relationships between such components. A new key contribution to the building of ever increasingly complex signal transduction networks appears in this issue of Genes & Development by Xiao et al. (2003). Using a combination of genetic analysis in the mouse and in vitro biochemical experiments in mammalian cells, those authors established that the adaptor . . . [Full Text of this Article]

	Role of Ecsit in Toll-like receptor signaling

 

	Role of Ecsit in embryonic development: Ecsit knockout phenocopies loss of BMP signal transduction

 

Ecsit as an effector of BMP signal transduction

	Crossing points between TGF- and Toll-like pathways: a signaling node that needs deeper (and genetic) definition

 

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