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Vol. 17, No. 7, pp. 819-825, April 1, 2003

REVIEW
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system

Kim Newton,¹ and Andreas Strasser^2,3

¹ Molecular Oncology Department, Genentech Inc., South San Francisco, California 94080, USA; ² The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, VIC 3050, Australia

The first 100 words of the full text of this article appear below.

	Introduction

Members of the caspase family of aspartate-specific cysteine proteases are best known for their involvement in apoptosis (human caspases 2, 3, 6, 7, 8, 9, 10; mouse caspases 2, 3, 6, 7, 8, 9, 12) and the maturation of cytokines such as IL-1 and IL-18 (human caspases 1, 4, 5; mouse caspases 1, 11; Thornberry and Lazebnik 1998; Shi 2002) . Recently, however, there have been a number of reports suggesting that caspases, in particular caspase 8, may have an additional role in the immune system promoting lymphocyte activation and proliferation (Chun et al. 2002; Salmena et al. 2003). The seemingly paradoxical observations that caspase 8 is critical for both activation and . . . [Full Text of this Article]

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