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GENES & DEVELOPMENT 18:597-601, 2004
©2004 by Cold Spring Harbor Laboratory Press; ISSN 0890-9369/ $5.00
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PERSPECTIVE

Exploiting quantitative trait loci in gene discovery

Sarah Hake1,3 and Torbert Rocheford2

1 Plant Gene Expression Center, U.S. Department of Agriculture-Agricultural Research Science, University of California, Berkeley, Albany, California 94710, USA; 2 Department of Crop Sciences, University of Illinois, Urbana, Illinois 61801, USA

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Developmental biologists prefer to study single gene mutations that produce large obvious changes, changes that may be accompanied by lethality or sterility. Such phenotypes are easy to find in genetic screens and reveal that the gene is required for early, fundamental processes, and thus is important for the organism. Natural variation, however, does not work that way; mutations that lead to sterility or embryonic lethality are quickly weeded out. The alleles selected by nature contribute to survival of the organism, not its detriment. In addition, the variation between two different, naturally occurring populations is not likely to be due to . . . [Full Text of this Article]


   Identifying alleles responsible for natural variation
 

   Identifying BRX, a naturally occurring allele that regulates root length
 

   Cloning QTL that regulate flowering time
 

   Identifying alleles selected during crop domestication
 

   Summary
 

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The Genetic Basis for Inflorescence Variation Between Foxtail and Green Millet (Poaceae)
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[Abstract] [Full Text] [PDF]


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Copyright © 2004 by Cold Spring Harbor Laboratory Press.