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PERSPECTIVE

Metabolism, ubiquinone synthesis, and longevity

Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA

The first 100 words of the full text of this article appear below.

"You have made your way from worm to man, but much within you is still a worm."

—Nieztsche

Until recently, the mechanisms that control the aging process were thought to be immensely complex and nearly impossible to dissect at the molecular level. However, genetic analysis, primarily in model organisms such as yeast, worms, and flies, is dramatically changing this view. It seems that at least three distinct genetic networks control the aging process. These networks include the insulin/IGF-1 signaling pathway, signaling that arises from the mitochondrial electron transport chain, and finally, mechanisms that govern the response to dietary restriction. The . . . [Full Text of this Article]

	Mitochondria and longevity

 

	Mitochondrial metabolic rate versus quality of ubiquinone pool

 

	Mutations and perturbations that alter mitochondrial function and life span

 

	clk-1

 

	How does reduced mitochondrial activity alter longevity?

 

	Future thoughts

 

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