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PERSPECTIVE

'No, really, how do they work?'

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA

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"How do the antidiabetic thiazolidinediones work?" If your 3-yr-old asked this question it would be easy to answer: "They function as agonists to activate PPAR." Inquisitive minds being what they are, this answer would suffice only for a moment and a more incisive query would soon follow: "But how does PPAR activation affect diabetes?" You could keep the cycle going for another round by responding: "When it is activated, PPAR turns on the expression of appropriate target genes that function to increase insulin sensitivity." And you might manage to delay the inevitable by handing her a printout of PPAR . . . [Full Text of this Article]

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