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PERSPECTIVE

Leukemia and lymphoma: a cost of doing business for adaptive immunity

Division of Immunology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA

The first 100 words of the full text of this article appear below.

According to the old adage, "you don’t get something for nothing." This is certainly the case for the novel genetic mechanisms involved in adaptive immunity—V(D)J recombination, class-switch recombination (CSR), and somatic hypermutation (SHM). These mechanisms allow animals to respond with great specificity to a seemingly limitless array of rapidly evolving microbes and their products while investing a relatively small amount of genetic capacity. The cost, however, is genomic instability and its potential contribution to malignancy. A majority of B- and T-cell leukemias and lymphomas are associated with chromosomal abnormalities that bear the hallmarks of aberrant V(D)J or class-switch recombination. In . . . [Full Text of this Article]

	Novel mechanisms regulating antigen receptor genes in lymphocytes

 

	Chromosomal translocations and lymphoid malignancy

 

	The V(D)J recombinase and genomic instability

 

	The V(D)J recombinase is a transposase

 

	Detection and quantification of RSS fragment transposition

 

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				J. D. Curry, D. Schulz, C. J. Guidos, J. S. Danska, L. Nutter, A. Nussenzweig, and M. S. Schlissel Chromosomal reinsertion of broken RSS ends during T cell development J. Exp. Med., October 1, 2007; 204(10): 2293 - 2303. [Abstract] [Full Text] [PDF]